TY - JOUR
T1 - Comparative Neuroimaging With Pathologic Correlates in Alexander's Disease
AU - Hess, David C
AU - Fischer, Asma Q.
AU - Yaghmai, Farivar
AU - Figueroa Ortiz, Ramon E
AU - Akamatsu, Yuki
PY - 1990/1/1
Y1 - 1990/1/1
N2 - We describe a case of pathologically confirmed Alexander's disease in which serial cranial ultrasound studies demonstrated unique findings of enlarging subependymal cysts with evolving periventricular hyperechogenicity. Computed tomographic scan of the head showed low attenuation of the periventricular white matter and centrum semiovale. Magnetic resonance imaging (MRI) demonstrated diffuse, confluent high signal predominantly in frontal white matter. These imaging modalities, particularly cranial ultrasound and MRI, may be useful tools in the diagnostic evaluation of children with degenerative neurologic disease, megalencephaly, and suspected Alexander's disease. (J Child Neurol 1990;5:248-252).
AB - We describe a case of pathologically confirmed Alexander's disease in which serial cranial ultrasound studies demonstrated unique findings of enlarging subependymal cysts with evolving periventricular hyperechogenicity. Computed tomographic scan of the head showed low attenuation of the periventricular white matter and centrum semiovale. Magnetic resonance imaging (MRI) demonstrated diffuse, confluent high signal predominantly in frontal white matter. These imaging modalities, particularly cranial ultrasound and MRI, may be useful tools in the diagnostic evaluation of children with degenerative neurologic disease, megalencephaly, and suspected Alexander's disease. (J Child Neurol 1990;5:248-252).
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U2 - 10.1177/088307389000500320
DO - 10.1177/088307389000500320
M3 - Article
C2 - 2398240
AN - SCOPUS:0024988770
SN - 0883-0738
VL - 5
SP - 248
EP - 252
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 3
ER -