Abstract
Objectives: This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) in the surgical reconstruction of peri-implantitis defects. Material and methods: Eight beagle dogs subject to ligature-induced peri-implantitis were used. The animals either received antimicrobial photodynamic therapy or topical tetracycline hydrochloride combined with GBR or as stand-alone surgical interventions. Block biopsies of the defect sites for histological analysis were obtained at euthanasia, 12 weeks postsurgery. The primary outcome of the study was re-osseointegration; secondary outcomes included alveolar bone gain and remaining defect characteristics. The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated. Results: No significant differences were observed between the two antimicrobial protocols, and the adjunctive use of GBR failed to significantly improve re-osseointegration or bone gain using either protocol. Buccal sites and implant early exposure negatively affected bone regeneration. Conclusion: Both antimicrobial therapies stand-alone or combined with GBR allowed similar and limited bone gain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1388-1395 |
| Number of pages | 8 |
| Journal | Clinical Oral Implants Research |
| Volume | 28 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2017 |
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Keywords
- animal experiments
- biomaterials
- bone regeneration
- bone substitutes
- guided tissue regeneration
- wound healing
ASJC Scopus subject areas
- Oral Surgery
Cite this
Comparison between two antimicrobial protocols with or without guided bone regeneration in the treatment of peri-implantitis. A histomorphometric study in dogs. / Ramos, Umberto Demoner; Suaid, Flavia Adelino; Wikesjö, Ulf M E; Susin, Cristiano; Taba, Mario; Novaes, Arthur Belém.
In: Clinical Oral Implants Research, Vol. 28, No. 11, 01.11.2017, p. 1388-1395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison between two antimicrobial protocols with or without guided bone regeneration in the treatment of peri-implantitis. A histomorphometric study in dogs
AU - Ramos, Umberto Demoner
AU - Suaid, Flavia Adelino
AU - Wikesjö, Ulf M E
AU - Susin, Cristiano
AU - Taba, Mario
AU - Novaes, Arthur Belém
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Objectives: This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) in the surgical reconstruction of peri-implantitis defects. Material and methods: Eight beagle dogs subject to ligature-induced peri-implantitis were used. The animals either received antimicrobial photodynamic therapy or topical tetracycline hydrochloride combined with GBR or as stand-alone surgical interventions. Block biopsies of the defect sites for histological analysis were obtained at euthanasia, 12 weeks postsurgery. The primary outcome of the study was re-osseointegration; secondary outcomes included alveolar bone gain and remaining defect characteristics. The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated. Results: No significant differences were observed between the two antimicrobial protocols, and the adjunctive use of GBR failed to significantly improve re-osseointegration or bone gain using either protocol. Buccal sites and implant early exposure negatively affected bone regeneration. Conclusion: Both antimicrobial therapies stand-alone or combined with GBR allowed similar and limited bone gain.
AB - Objectives: This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) in the surgical reconstruction of peri-implantitis defects. Material and methods: Eight beagle dogs subject to ligature-induced peri-implantitis were used. The animals either received antimicrobial photodynamic therapy or topical tetracycline hydrochloride combined with GBR or as stand-alone surgical interventions. Block biopsies of the defect sites for histological analysis were obtained at euthanasia, 12 weeks postsurgery. The primary outcome of the study was re-osseointegration; secondary outcomes included alveolar bone gain and remaining defect characteristics. The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated. Results: No significant differences were observed between the two antimicrobial protocols, and the adjunctive use of GBR failed to significantly improve re-osseointegration or bone gain using either protocol. Buccal sites and implant early exposure negatively affected bone regeneration. Conclusion: Both antimicrobial therapies stand-alone or combined with GBR allowed similar and limited bone gain.
KW - animal experiments
KW - biomaterials
KW - bone regeneration
KW - bone substitutes
KW - guided tissue regeneration
KW - wound healing
UR - http://www.scopus.com/inward/record.url?scp=85008230623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008230623&partnerID=8YFLogxK
U2 - 10.1111/clr.12998
DO - 10.1111/clr.12998
M3 - Article
C2 - 28054383
AN - SCOPUS:85008230623
VL - 28
SP - 1388
EP - 1395
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
SN - 0905-7161
IS - 11
ER -