Comparison between two antimicrobial protocols with or without guided bone regeneration in the treatment of peri-implantitis. A histomorphometric study in dogs

Umberto Demoner Ramos, Flavia Adelino Suaid, Ulf M E Wikesjö, Cristiano Susin, Mario Taba, Arthur Belém Novaes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) in the surgical reconstruction of peri-implantitis defects. Material and methods: Eight beagle dogs subject to ligature-induced peri-implantitis were used. The animals either received antimicrobial photodynamic therapy or topical tetracycline hydrochloride combined with GBR or as stand-alone surgical interventions. Block biopsies of the defect sites for histological analysis were obtained at euthanasia, 12 weeks postsurgery. The primary outcome of the study was re-osseointegration; secondary outcomes included alveolar bone gain and remaining defect characteristics. The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated. Results: No significant differences were observed between the two antimicrobial protocols, and the adjunctive use of GBR failed to significantly improve re-osseointegration or bone gain using either protocol. Buccal sites and implant early exposure negatively affected bone regeneration. Conclusion: Both antimicrobial therapies stand-alone or combined with GBR allowed similar and limited bone gain.

Original languageEnglish (US)
Pages (from-to)1388-1395
Number of pages8
JournalClinical Oral Implants Research
Volume28
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Peri-Implantitis
Bone Regeneration
Dogs
Osseointegration
Bone and Bones
Therapeutics
Euthanasia
Cheek
Photochemotherapy
Tetracycline
Ligation
Outcome Assessment (Health Care)
Biopsy

Keywords

  • animal experiments
  • biomaterials
  • bone regeneration
  • bone substitutes
  • guided tissue regeneration
  • wound healing

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Comparison between two antimicrobial protocols with or without guided bone regeneration in the treatment of peri-implantitis. A histomorphometric study in dogs. / Ramos, Umberto Demoner; Suaid, Flavia Adelino; Wikesjö, Ulf M E; Susin, Cristiano; Taba, Mario; Novaes, Arthur Belém.

In: Clinical Oral Implants Research, Vol. 28, No. 11, 01.11.2017, p. 1388-1395.

Research output: Contribution to journalArticle

Ramos, Umberto Demoner ; Suaid, Flavia Adelino ; Wikesjö, Ulf M E ; Susin, Cristiano ; Taba, Mario ; Novaes, Arthur Belém. / Comparison between two antimicrobial protocols with or without guided bone regeneration in the treatment of peri-implantitis. A histomorphometric study in dogs. In: Clinical Oral Implants Research. 2017 ; Vol. 28, No. 11. pp. 1388-1395.
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