Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures

James M. Heit, Mark R Stevens, Keith Jeffords

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose. The purpose of the study was to compare the efficacy and cost of two antibiotic regimens for prophylaxis of compound mandible fractures: 1 gm/day ceftriaxone and 2 million U penicillin G every 4 hours. Design. A prospective study of 90 patients with compound mandible fractures was performed. The patients were randomized to the two antibiotic regimens. The surgical procedures were performed by oral/maxillofacial surgery residents at a large urban training center. Standard treatment consisted of open reduction with either bone plates or wires, with all patients receiving 6 weeks of maxillomandibular fixation. The patients were monitored at 2-week intervals for 8 weeks by two of the authors, who were blinded to which antibiotic regimen the patient was assigned. Results. Two patients in each group had postoperative infections within the first 2 weeks of treatment. The infections resolved with local wound care, removal of internal fixation devices, and oral antibiotics. After resolution of the infection each patient had a malunion, which was managed without additional complications. The cost difference between the two treatment regimens was approximately $350 per day. Conclusion. Ceftriaxone was noted to be an efficacious and cost-effective treatment alternative to penicillin G for compound mandible fracture antibiotic prophylaxis.

Original languageEnglish (US)
Pages (from-to)423-426
Number of pages4
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume83
Issue number4
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Open Fractures
Antibiotic Prophylaxis
Ceftriaxone
Mandible
Penicillins
Penicillin G
Oral Surgery
Anti-Bacterial Agents
Jaw Fixation Techniques
Infection
Internal Fixators
Bone Plates
Bone Wires
Costs and Cost Analysis
Health Care Costs
Therapeutics
Prospective Studies
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Comparison of ceftriaxone with penicillin for antibiotic prophylaxis for compound mandible fractures. / Heit, James M.; Stevens, Mark R; Jeffords, Keith.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 83, No. 4, 01.01.1997, p. 423-426.

Research output: Contribution to journalArticle

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