Comparison of conjunctival and corneal surface areas in rabbit and human

Mitchell A. Watsky, Monica M. Jablonski, Henry F. Edelhauser

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

This comparative study shows the surface area ratio of conjunctiva to cornea to be two times larger in humans than in rabbits. This large heretofore unrecognized interspecies difference may affect the applicability of drug pharmacokinetic data obtained using rabbit models and should be taken into consideration in topical drug development and future comparative drug penetration studies between rabbit and man.

Original languageEnglish (US)
Pages (from-to)483-486
Number of pages4
JournalCurrent Eye Research
Volume7
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Rabbits
Pharmaceutical Preparations
Conjunctiva
Cornea
Pharmacokinetics

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Comparison of conjunctival and corneal surface areas in rabbit and human. / Watsky, Mitchell A.; Jablonski, Monica M.; Edelhauser, Henry F.

In: Current Eye Research, Vol. 7, No. 5, 01.01.1988, p. 483-486.

Research output: Contribution to journalArticle

Watsky, Mitchell A. ; Jablonski, Monica M. ; Edelhauser, Henry F. / Comparison of conjunctival and corneal surface areas in rabbit and human. In: Current Eye Research. 1988 ; Vol. 7, No. 5. pp. 483-486.
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