Comparison of incidence of invasive Streptococcus pneumonioe disease among children before and after introduction of conjugated pneumococcal vaccine

Richard I. Haddy, Kelvin Perry, Chris E. Chacko, William B. Helton, Mark G. Bowling, Stephen Warwick Looney, George E. Buck

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objectives: The objective was to determine whether there has been a significant decrease in the incidence of invasive Streptococcus pneumoniae disease in the Louisville, KY, area since heptavalent pneumococcal conjugate vaccine was introduced in the winter of 1999-2000. A secondary objective was to collect demographic data regarding invasive S. pneumoniae disease in the Louisville, KY, area during the 1997-2002 period. Methods: Data on cases of invasive S. pneumoniae disease (defined by a positive culture for S. pneumoniae from the blood, pleural fluid or cerebrospinal fluid) were collected from the microbiology laboratories and medical records departments of all hospitals that treat children in the Louisville area, for 1997-2002. Trends in case rates for all cases of invasive S. pneumoniae disease from 1999 to 2002 were observed, and demographic and other factors regarding this illness were recorded for each patient. Results: The trend for rates of invasive pneumococcal disease showed a significant decrease during the study period for all ages combined (P < 0.001), for children younger than 2 years of age (P = 0.002) and for children 2 to 5 years of age (P = 0.002). The mean age for children was 2.22 years, with a male/female ratio of 1.8:1. The most common final diagnoses for the patients were bacteremia without focus, pneumonia and meningitis. Forty-eight percent of the organisms were resistant to penicillin. There was a significantly higher rate of resistance to penicillin among S. pneumoniae strains that caused cerebrospinal fluid infection than among strains that caused non-cerebrospinal fluid infection (P < 0.001). The case fatality rate was 2.6%. Conclusion: Case rates for invasive S. pneumoniae disease among children decreased significantly in the 2-year period after introduction of the heptavalent S. pneumonia protein conjugate vaccine into this community.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalPediatric Infectious Disease Journal
Volume24
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

Fingerprint

Pneumococcal Vaccines
Streptococcus pneumoniae
Streptococcus
Incidence
Cerebrospinal Fluid
Pneumonia
Hospital Medical Records Department
Demography
Penicillin Resistance
Conjugate Vaccines
Protein S
Bacteremia
Microbiology
Infection
Meningitis
Penicillins
Mortality

Keywords

  • Invasive
  • Pediatrics
  • Pneumococcus
  • Vaccine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

Cite this

Comparison of incidence of invasive Streptococcus pneumonioe disease among children before and after introduction of conjugated pneumococcal vaccine. / Haddy, Richard I.; Perry, Kelvin; Chacko, Chris E.; Helton, William B.; Bowling, Mark G.; Looney, Stephen Warwick; Buck, George E.

In: Pediatric Infectious Disease Journal, Vol. 24, No. 4, 01.04.2005, p. 320-323.

Research output: Contribution to journalArticle

Haddy, Richard I. ; Perry, Kelvin ; Chacko, Chris E. ; Helton, William B. ; Bowling, Mark G. ; Looney, Stephen Warwick ; Buck, George E. / Comparison of incidence of invasive Streptococcus pneumonioe disease among children before and after introduction of conjugated pneumococcal vaccine. In: Pediatric Infectious Disease Journal. 2005 ; Vol. 24, No. 4. pp. 320-323.
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AU - Looney, Stephen Warwick

AU - Buck, George E.

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N2 - Objectives: The objective was to determine whether there has been a significant decrease in the incidence of invasive Streptococcus pneumoniae disease in the Louisville, KY, area since heptavalent pneumococcal conjugate vaccine was introduced in the winter of 1999-2000. A secondary objective was to collect demographic data regarding invasive S. pneumoniae disease in the Louisville, KY, area during the 1997-2002 period. Methods: Data on cases of invasive S. pneumoniae disease (defined by a positive culture for S. pneumoniae from the blood, pleural fluid or cerebrospinal fluid) were collected from the microbiology laboratories and medical records departments of all hospitals that treat children in the Louisville area, for 1997-2002. Trends in case rates for all cases of invasive S. pneumoniae disease from 1999 to 2002 were observed, and demographic and other factors regarding this illness were recorded for each patient. Results: The trend for rates of invasive pneumococcal disease showed a significant decrease during the study period for all ages combined (P < 0.001), for children younger than 2 years of age (P = 0.002) and for children 2 to 5 years of age (P = 0.002). The mean age for children was 2.22 years, with a male/female ratio of 1.8:1. The most common final diagnoses for the patients were bacteremia without focus, pneumonia and meningitis. Forty-eight percent of the organisms were resistant to penicillin. There was a significantly higher rate of resistance to penicillin among S. pneumoniae strains that caused cerebrospinal fluid infection than among strains that caused non-cerebrospinal fluid infection (P < 0.001). The case fatality rate was 2.6%. Conclusion: Case rates for invasive S. pneumoniae disease among children decreased significantly in the 2-year period after introduction of the heptavalent S. pneumonia protein conjugate vaccine into this community.

AB - Objectives: The objective was to determine whether there has been a significant decrease in the incidence of invasive Streptococcus pneumoniae disease in the Louisville, KY, area since heptavalent pneumococcal conjugate vaccine was introduced in the winter of 1999-2000. A secondary objective was to collect demographic data regarding invasive S. pneumoniae disease in the Louisville, KY, area during the 1997-2002 period. Methods: Data on cases of invasive S. pneumoniae disease (defined by a positive culture for S. pneumoniae from the blood, pleural fluid or cerebrospinal fluid) were collected from the microbiology laboratories and medical records departments of all hospitals that treat children in the Louisville area, for 1997-2002. Trends in case rates for all cases of invasive S. pneumoniae disease from 1999 to 2002 were observed, and demographic and other factors regarding this illness were recorded for each patient. Results: The trend for rates of invasive pneumococcal disease showed a significant decrease during the study period for all ages combined (P < 0.001), for children younger than 2 years of age (P = 0.002) and for children 2 to 5 years of age (P = 0.002). The mean age for children was 2.22 years, with a male/female ratio of 1.8:1. The most common final diagnoses for the patients were bacteremia without focus, pneumonia and meningitis. Forty-eight percent of the organisms were resistant to penicillin. There was a significantly higher rate of resistance to penicillin among S. pneumoniae strains that caused cerebrospinal fluid infection than among strains that caused non-cerebrospinal fluid infection (P < 0.001). The case fatality rate was 2.6%. Conclusion: Case rates for invasive S. pneumoniae disease among children decreased significantly in the 2-year period after introduction of the heptavalent S. pneumonia protein conjugate vaccine into this community.

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