Comparison of sonohysterography to hysterosalpingogram for tubal patency assessment in a multicenter fertility treatment trial among women with polycystic ovary syndrome

Mindy S. Christianson, Richard S. Legro, Susan Jin, Esther Eisenberg, Michael Peter Diamond, Karl R. Hansen, Wendy Vitek, Aaron K. Styer, Peter Casson, Christos Coutifaris, Gregory M. Christman, Ruben Alvero, Elizabeth E. Puscheck, Alicia Y. Christy, Fangbai Sun, Heping Zhang, Alex J. Polotsky, Nanette Santoro

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Purpose To compare saline infusion sonohysterography (SIS) versus hysterosalpingogram (HSG) for confirmation of tubal patency. Methods Secondary analysis of a randomized controlled trial, Pregnancy in Polycystic Ovary Syndrome II (PPCOS II). Seven hundred fifty infertile women (18–40 years old) with polycystic ovary syndrome (PCOS) were randomized to up to 5 cycles of letrozole or clomiphene citrate. Prior to enrollment, tubal patency was determined by HSG, the presence of free fluid in the pelvis on SIS, laparoscopy, or recent intrauterine pregnancy. Logistic regression was conducted in patients who ovulated with clinical pregnancy as the outcome and HSG or SIS as the key independent variable. Results Among women who ovulated, 414 (66.9%) had tubal patency confirmed by SIS and 187 (30.2%) had at least one tube patent on HSG. Multivariable analysis indicated that choice of HSG versus SIS did not have a significant relationship on likelihood of clinical pregnancy, after adjustment for treatment arm, BMI, duration of infertility, smoking, and education (OR 1.14, 95% CI 0.77, 1.67, P = 0.52). Ectopic pregnancy occurred more often in women who had tubal patency confirmed by HSG compared to SIS (2.8% versus 0.6%, P =0.02). Conclusions In this large cohort of women with PCOS, there was no significant difference in clinical pregnancy rate between women who had tubal patency confirmed by HSG versus SIS. SIS is an acceptable imaging modality for assessment of tubal patency in this population.

Original languageEnglish (US)
Pages (from-to)2173-2180
Number of pages8
JournalJournal of Assisted Reproduction and Genetics
Volume35
Issue number12
DOIs
StatePublished - Dec 2018

Keywords

  • Hysterosalpingography
  • Polycystic ovary syndrome
  • Saline infusion sonohysterography
  • Saline ultrasound

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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