Comparison of two brands of clomiphene citrate for stimulation of follicular development in a program for in vitro fertilization

Michael Peter Diamond, C. M. Herbert, W. S. Maxson, A. Colston Wentz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Although clomiphene citrate (CC) is used frequently to stimulate multiple follicular development in in vitro fertilization programs, comparison of the two commercially available types has been limited. Therefore, a comparison was made of Serophene (Serono Laboratories, Inc., Randolph, MA) and Clomid (Merrell Dow Pharmaceuticals, Inc., Cincinnati, OH), using the same dosage regimen of CC (150 mg/day for days 3 to 7 of the cycle). Weights and ages of the two groups were not different. Serum estradiol (E2) levels were significantly elevated in Clomid cycles, but the number of developing follicles was not different between the two brands. The percentages of patients in each group who underwent laparoscopy, oocyte recovery, oocyte fertilization, and embryo transfer were also equivalent. Among patients undergoing laparoscopy, no differences in oocyte recovery, oocyte fertilization, and embryo development were noted. Thus, despite greater elevation of serum E2 levels with Clomid, no difference in stimulation regimen outcome was observed.

Original languageEnglish (US)
Pages (from-to)522-525
Number of pages4
JournalFertility and Sterility
Volume45
Issue number4
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Clomiphene
Fertilization in Vitro
Oocytes
Fertilization
Laparoscopy
Embryo Transfer
Serum
Embryonic Development
Estradiol
Age Groups
Weights and Measures
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Comparison of two brands of clomiphene citrate for stimulation of follicular development in a program for in vitro fertilization. / Diamond, Michael Peter; Herbert, C. M.; Maxson, W. S.; Colston Wentz, A.

In: Fertility and Sterility, Vol. 45, No. 4, 01.01.1986, p. 522-525.

Research output: Contribution to journalArticle

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