Compartmentalization of redox signaling through NaDPH oxidase-derived rOS

Research output: Contribution to journalReview article

239 Citations (Scopus)

Abstract

Reactive oxygen species (ROS) are generated in response to growth factors, cytokines, G protein-coupled receptor agonists, or shear stress, and function as signaling molecules in nonphagocytes. However, it is poorly understood how freely diffusible ROS can activate specific signaling, so-called ''redox signaling.'' NaDPH oxidases are a major source of ROS and now recognized to have specific subcellular localizations, and this targeting to specific compartments is required for localized ROS production. One important mechanism may involve the interaction of oxidase subunits with various targeting proteins localized in lamellipodial leading edge and focal adhesions=complexes. ROS are believed to inactivate protein tyrosine phosphatases, thereby establishing a positive-feedback system that promotes activation of specific redox signaling pathways involved in various functions. additionally, ROS production may be localized through interactions of NaDPH oxidase with signaling platforms associated with caveolaelipid rafts, endosomes, and nucleus. These indicate that the specificity of ROS-mediated signal transduction may be modulated by the localization of Nox isoforms and their regulatory subunits within specific subcellular compartments. This review summarizes the recent progress on compartmentalization of redox signaling via activation of NaDPH oxidase, which is implicated in cell biology and pathophysiologies.

Original languageEnglish (US)
Pages (from-to)1289-1299
Number of pages11
JournalAntioxidants and Redox Signaling
Volume11
Issue number6
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

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Oxidation-Reduction
Reactive Oxygen Species
Oxidoreductases
Chemical activation
Cytology
Signal transduction
Protein Tyrosine Phosphatases
Focal Adhesions
Endosomes
Protein Transport
G-Protein-Coupled Receptors
Cell Biology
Shear stress
Signal Transduction
Intercellular Signaling Peptides and Proteins
Protein Isoforms
Adhesion
Cytokines
Feedback
Molecules

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Compartmentalization of redox signaling through NaDPH oxidase-derived rOS. / Fukai, Masuko.

In: Antioxidants and Redox Signaling, Vol. 11, No. 6, 01.06.2009, p. 1289-1299.

Research output: Contribution to journalReview article

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