Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function

Yang Z. Huang, Qiang Wang, Sandra Won, Zhen G. Luo, Wencheng Xiong, Lin Mei

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The synapse-specific synthesis of the acetylcholine receptor (AChR) is mediated by multiple mechanisms including compartmentalized signaling induced by neuregulin (NRG). This paper presents evidence that NRG receptors - ErbB receptor tyrosine kinases interact with distinct PDZ domain-containing proteins that are localized at the neuromuscular junction (NMJ). ErbB4 associates with the PSD-95 (also known as SAP90)-family members including PSD-95, SAP97, and SAP102 whereas ErbB2 interacts with Erbin and PICK1. Although, ErbB kinases are concentrated at the NMJ, they are not colocalized with the AChR in cultured muscle cells even in the presence of agrin. Co-expression of PSD-95 causes ErbB4 to form clusters in COS cells. We propose that PDZ domain-containing proteins play a role in anchoring ErbB proteins at the neuromuscular junction, and/or mediating downstream signaling pathways. Such mechanisms could be important for the maintenance and function of the synapse.

Original languageEnglish (US)
Pages (from-to)173-185
Number of pages13
JournalInternational Journal of Developmental Neuroscience
Volume20
Issue number3-5
DOIs
StatePublished - Aug 26 2002

Fingerprint

Neuregulins
PDZ Domains
Neuromuscular Junction
Synapses
Cholinergic Receptors
Agrin
Proteins
COS Cells
Protein-Tyrosine Kinases
Muscle Cells
Cultured Cells
Phosphotransferases
Maintenance

Keywords

  • Acetylcholine receptor
  • Neuregulin
  • Neuromuscular junction
  • Synapse
  • Synaptogenesis

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Cite this

Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. / Huang, Yang Z.; Wang, Qiang; Won, Sandra; Luo, Zhen G.; Xiong, Wencheng; Mei, Lin.

In: International Journal of Developmental Neuroscience, Vol. 20, No. 3-5, 26.08.2002, p. 173-185.

Research output: Contribution to journalArticle

Huang, Yang Z. ; Wang, Qiang ; Won, Sandra ; Luo, Zhen G. ; Xiong, Wencheng ; Mei, Lin. / Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. In: International Journal of Developmental Neuroscience. 2002 ; Vol. 20, No. 3-5. pp. 173-185.
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