Compensation for partial lipectomy in mice with genetic alterations of leptin and its receptor subtypes

Ruth B.S. Harris, Dorothy B. Hausman, Timothy J. Bartness

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


One hypothesis for the regulation of total body fat suggests that leptin is a lipostatic feedback signal that acts at brain sites involved in regulation of energy balance. The importance of leptin in recovery from partial surgical lipectomy was tested by performing bilateral epididymal lipectomy or sham surgery on wild-type and leptin-deficient ob/ob mice. Eight weeks later, nonexcised pads of lipectomized mice were increased but total carcass fat was lower than in sham-operated ob/ob mice. In experiment 2, ob/ob mice, wild-type mice, and two db/db mutants, C57BL/6J dbLepr/ dbLepr (BL/6J) mice possessing short-form and circulating leptin receptors and C57BL/6J db3J/db3J (BL/3J) mice expressing only circulating receptors, were lipectomized or sham operated. Sixteen weeks later, body mass and carcass lipid were not different between sham and lipectomized ob/ob mice, wild-type mice, or BL/6J db/db mice, whereas there was incomplete (decreased carcass fat) but suggestive recovery (increased retroperitoneal fat mass and cell number) in lipectomized BL/3J db/db mice. These data indicate that leptin is not required for the regulation of total body fat.

Original languageEnglish (US)
Pages (from-to)R1094-R1103
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Issue number5 52-5
StatePublished - Nov 1 2002
Externally publishedYes


  • Cell size distribution
  • Db/db mice
  • Ob/ob mice
  • Total body fat

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Compensation for partial lipectomy in mice with genetic alterations of leptin and its receptor subtypes'. Together they form a unique fingerprint.

Cite this