Compensatory growth of adipose tissue after partial lipectomy: Involvement of serum factors

Dorothy B. Hausman, Jie Lu, Donna H. Ryan, William P. Flatt, Ruth Babette Harris

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The regulation of body weight/fat was studied by investigating mechanisms for compensatory adipose tissue growth after removal of bilateral epididymal fat pads from male adult Wistar rats. Food intake during the first 4 weeks and energy expenditure on Days 8-10 postsurgery were not different between lipectomized and sham operated rats. During Days 29-31 post surgery, a small (2.4%) but significant (P < 0.05) increase in heat production per metabolic body size was detected in lipectomized as compared with sham operated rats. The carcass composition of lipectomized and sham operated rats was not significantly different 16 weeks after surgery. The compensatory growth was fat pad-specific: mesenteric, retroperitoneal, and inguinal fat pads, but not perirenal fat pads, were heavier in lipectomized rats than in sham operated rats as early as 4 weeks postsurgery. Examination of fat cell size distribution in the compensating pads indicated a shift toward larger cells in retroperitoneal fat, but not in inguinal fat of lipectomized as compared with sham operated rats. Serum from lipectomized rats, but not media conditioned by exposure to retroperitoneal fat pads from lipectomized rats, stimulated proliferation of preadipocytes in vitro more than that from sham operated rats. Thus, compensatory adipose tissue growth after lipectomy may be mediated, in part, by blood-borne factors that are derived from tissues other than adipose tissue.

Original languageEnglish (US)
Pages (from-to)512-520
Number of pages9
JournalExperimental Biology and Medicine
Volume229
Issue number6
DOIs
StatePublished - Jan 1 2004

Fingerprint

Lipectomy
Adipose Tissue
Rats
Tissue
Fats
Growth
Serum
Intra-Abdominal Fat
Groin
Surgery
Thermogenesis
Body Size
Thromboplastin
Conditioned Culture Medium
Cell Size
Adipocytes
Energy Metabolism
Wistar Rats
Eating
Body Weight

Keywords

  • Adipocyte proliferation
  • Adiposity signals
  • Energy expenditure
  • Obesity
  • Paracrine factors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Compensatory growth of adipose tissue after partial lipectomy : Involvement of serum factors. / Hausman, Dorothy B.; Lu, Jie; Ryan, Donna H.; Flatt, William P.; Harris, Ruth Babette.

In: Experimental Biology and Medicine, Vol. 229, No. 6, 01.01.2004, p. 512-520.

Research output: Contribution to journalArticle

Hausman, Dorothy B. ; Lu, Jie ; Ryan, Donna H. ; Flatt, William P. ; Harris, Ruth Babette. / Compensatory growth of adipose tissue after partial lipectomy : Involvement of serum factors. In: Experimental Biology and Medicine. 2004 ; Vol. 229, No. 6. pp. 512-520.
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