Complementarity and Uncertainty in Intrafibrillar Mineralization of Collagen

Kai Jiao, Li Na Niu, Chu Fan Ma, Xue Qing Huang, Dan Dan Pei, Tao Luo, Qi Huang, Ji Hua Chen, Franklin Chi Meng Tay

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Biomineralization in vertebrates is a ubiquitous and tightly regulated process which creates hierarchical structures for the skeleton. Because of the lack of understanding and applicability of cell-based or biological systems to achieve intrafibrillar mineralization, scientists adopted various in vitro methods to elucidate the mechanism of intrafibrillar mineralization. In this article, biomimetic intrafibrillar mineralization of collagen in its wide ramifications is reviewed. It is intriguing how prevailing intrafibrillar mineralization mechanisms derived from two potentially discordant crystallization philosophies were equally adept, depending on the experimental context, at theorizing the formation of calcium phosphate within a fibrillar template. This complementarity is not unique to biomineralization and has precedence in other fundamental physical interpretations. A new intrafibrillar mineralization process based on the use of polycationic process-directing agent added uncertainty to the use of existing mechanisms in accounting for the observations.

Original languageEnglish (US)
Pages (from-to)6858-6875
Number of pages18
JournalAdvanced Functional Materials
Volume26
Issue number38
DOIs
StatePublished - Oct 11 2016

Fingerprint

Biomineralization
collagens
Collagen
Calcium phosphate
Biomimetics
Biological systems
Crystallization
vertebrates
calcium phosphates
biomimetics
musculoskeletal system
templates
crystallization
cells
Uncertainty
calcium phosphate
icodextrin

Keywords

  • biomineralization
  • collagen
  • intrafibrillar
  • polyallylamines
  • polycations

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Complementarity and Uncertainty in Intrafibrillar Mineralization of Collagen. / Jiao, Kai; Niu, Li Na; Ma, Chu Fan; Huang, Xue Qing; Pei, Dan Dan; Luo, Tao; Huang, Qi; Chen, Ji Hua; Tay, Franklin Chi Meng.

In: Advanced Functional Materials, Vol. 26, No. 38, 11.10.2016, p. 6858-6875.

Research output: Contribution to journalArticle

Jiao, K, Niu, LN, Ma, CF, Huang, XQ, Pei, DD, Luo, T, Huang, Q, Chen, JH & Tay, FCM 2016, 'Complementarity and Uncertainty in Intrafibrillar Mineralization of Collagen', Advanced Functional Materials, vol. 26, no. 38, pp. 6858-6875. https://doi.org/10.1002/adfm.201602207
Jiao, Kai ; Niu, Li Na ; Ma, Chu Fan ; Huang, Xue Qing ; Pei, Dan Dan ; Luo, Tao ; Huang, Qi ; Chen, Ji Hua ; Tay, Franklin Chi Meng. / Complementarity and Uncertainty in Intrafibrillar Mineralization of Collagen. In: Advanced Functional Materials. 2016 ; Vol. 26, No. 38. pp. 6858-6875.
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