Comprehensive allelotype and genetic analysis of 466 human nervous system tumors

Andreas Von Deimling, Rolf Fimmers, Matthias C. Schmidt, Bernhard Bender, Frank Fassbender, Judith Nagel, Rolf Jahnke, Peter Kaskel, Eva Maria Duerr, Jens Koopmann, David Maintz, Stephanie Steinbeck, Wolfgang Wick, Michael Platten, Daniel J. Müller, René Przkora, Andreas Waha, Britta Blümcke, Ruth Wellenreuther, Birgit Meyer-PuttlitzOrtrud Schmidt, Jan Mollenhauer, Annemarie Poustka, Armin P. Stangl, Doris Lenartz, Klaus Von Ammon, John W. Henson, Johannes Schramm, David N. Louis, Otmar D. Wiestler

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

Brain tumors pose a particular challenge to molecular oncology. Many different tumor entities develop in the nervous system and some of them appear to follow distinct pathogenic routes. Molecular genetic alterations have increasingly been reported in nervous system neoplasms. However, a considerable number of affected genes remain to be identified. We present here a comprehensive allelotype analysis of 466 nervous system tumors based on loss of heterozygosity (LOH) studies with 129 microsatellite markers that span the genome. Specific alterations of the EGFR, CDK4, CDKN2A, TP53, DMBTI, NF2, and PTEN genes were analyzed in addition. Our data point to several novel genetic loci associated with brain tumor development, demonstrate relationships between molecular changes and histopathological features, and further expand the concept of molecular tumor variants in neuro-oncology. This catalogue may provide a valuable framework for future studies to delineate molecular pathways in many types of human central nervous system tumors.

Original languageEnglish (US)
Pages (from-to)544-558
Number of pages15
JournalJournal of Neuropathology and Experimental Neurology
Volume59
Issue number6
DOIs
StatePublished - Jun 2000
Externally publishedYes

Keywords

  • Allelotype
  • Brain
  • Molecular genetics
  • Mutation
  • Tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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