COMT158 Polymorphism and Hostility

Jan Volavka; James L. Kennedy; Xingqun Ni; Pal Czobor; Karen Nolan; Brian Sheitman; Jean Pierre Lindenmayer; Leslie Citrome; Joseph Patrick McEvoy; Jeffrey A. Lieberman

doi:10.1002/ajmg.b.20149

COMT158 Polymorphism and Hostility

Jan Volavka, James L. Kennedy, Xingqun Ni, Pal Czobor, Karen Nolan, Brian Sheitman, Jean Pierre Lindenmayer, Leslie Citrome, Joseph Patrick McEvoy, Jeffrey A. Lieberman

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.

Original language	English (US)
Pages (from-to)	28-29
Number of pages	2
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	127 B
Issue number	1
DOIs	https://doi.org/10.1002/ajmg.b.20149
State	Published - May 15 2004
Externally published	Yes

Keywords

Aggression
Catechol-O-methyltransferase
Schizoaffective disorder
Schizophrenia

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ajmg.b.20149

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title = "COMT158 Polymorphism and Hostility",

abstract = "The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.",

keywords = "Aggression, Catechol-O-methyltransferase, Schizoaffective disorder, Schizophrenia",

author = "Jan Volavka and Kennedy, {James L.} and Xingqun Ni and Pal Czobor and Karen Nolan and Brian Sheitman and Lindenmayer, {Jean Pierre} and Leslie Citrome and McEvoy, {Joseph Patrick} and Lieberman, {Jeffrey A.}",

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T1 - COMT158 Polymorphism and Hostility

AU - Volavka, Jan

AU - Kennedy, James L.

AU - Ni, Xingqun

AU - Czobor, Pal

AU - Nolan, Karen

AU - Sheitman, Brian

AU - Lindenmayer, Jean Pierre

AU - Citrome, Leslie

AU - McEvoy, Joseph Patrick

AU - Lieberman, Jeffrey A.

PY - 2004/5/15

Y1 - 2004/5/15

N2 - The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.

AB - The main study was designed primarily to compare the clinical effects of four antipsychotics in 157 patients with schizophrenia or schizoaffective disorder. The secondary genetic study, reported here, is based on a subset of 60 patients who consented to genotyping assays. Based on previous work with the catechol-O-methyltransferase (COMT) 158 polymorphism, we hypothesized that the Met-Met homozygotes would be more hostile than the heterozygotes and the Val-Val homozygotes. Hostility ratings at baseline were used to test this hypothesis. The Met-Met homozygotes (N = 7) were found to have significantly higher levels of hostility than the other patients (N = 53). The hypothesis was thus supported. The finding should be replicated in a larger sample.

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KW - Catechol-O-methyltransferase

KW - Schizoaffective disorder

KW - Schizophrenia

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COMT158 Polymorphism and Hostility

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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