Concentrations of serum free light chains in kappa and lambda lesions in light-Chain myelomas

Research output: Contribution to journalArticle

Abstract

Background: Concentration of serum free light chains has been promoted as an assay in the evaluation of monoclonal gammopathic manifestations. A high false-positive rate in patients without monoclonal gammopathic manifestations and a high false-negative rate in patients with those manifestations have been reported. The false-negative rate for lambda chain-associated lesions is higher than that for kappa chain-associated lesions. Objective: To assess the serum free light chains in light-chain myelomas. Methods: Concentrations of involved and uninvolved serum free light chains were retrospectively reviewed in patients with light-chain myelomas. Results: The highest recorded levels of involved light chains in kappachain myelomas and lambda-chain myelomas were comparable. The levels of uninvolved light chains were higher, although not statistically significantly, in lambda-chain lesions. Conclusions: The results of serum free light chains in light-chain myelomas support the clinical usefulness of the assay in monitoring patients with light chain myeloma.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalLab Medicine
Volume50
Issue number2
DOIs
StatePublished - Jan 1 2019

Keywords

  • Light-chain myeloma
  • Monoclonal gammopathy
  • Multiple myeloma
  • Serum free light chains
  • Serum protein electrophoresis
  • Urine protein electrophoresis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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