Concomitants of asymptomatic retinal cholesterol emboli

Askiel Bruno, Patrick W. Russell, William L. Jones, Jeffrey K. Austin, Eric S. Weinstein, Susan R. Steel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background and Purpose: Asymptomatic retinal cholesterol emboli are sometimes encountered on ophthalmoscopic examination. They are associated with decreased survival, but their clinical significance is not fully known. We sought to determine which vascular risk factors are associated with such emboli. Methods: We studied 70 consecutive men (55–84 years old) with asymptomatic retinal cholesterol emboli diagnosed in an eye clinic Twenty-one men (57–78 years old) from the same eye clinic without retinal emboli or retinal ischemic events were randomly selected as control subjects. We determined vascular risk factors, presence of ischemic heart disease, and extracranial carotid artery disease. Results: Patients had a higher prevalence of hypertension, smoked more, and had a higher prevalence of heterogeneous or echolucent carotid plaques on either side than did control subjects (p <0.001 for all three factors). Patients also had a higher prevalence of carotid artery stenosis ≥ 50% on either side and a higher prevalence of ischemic heart disease than did control subjects, but these did not reach statistical significance (p = 0.06and p = 0.08, respectively). Conclusions: Our findings suggest that hypertension and cigarette smoking may be important in the pathogenesis of asymptomatic retinal cholesterol emboli and that these emboli indicate systemic atherosclerosis rather than ipsilateral carotid artery stenosis.

Original languageEnglish (US)
Pages (from-to)900-902
Number of pages3
JournalStroke
Volume23
Issue number6
DOIs
StatePublished - Jan 1 1992

Fingerprint

Embolism
Cholesterol
Carotid Stenosis
Myocardial Ischemia
Hypertension
Carotid Artery Diseases
Atherosclerosis
Smoking
Survival

Keywords

  • Embolism
  • Retina
  • Risk factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Bruno, A., Russell, P. W., Jones, W. L., Austin, J. K., Weinstein, E. S., & Steel, S. R. (1992). Concomitants of asymptomatic retinal cholesterol emboli. Stroke, 23(6), 900-902. https://doi.org/10.1161/01.STR.23.6.900

Concomitants of asymptomatic retinal cholesterol emboli. / Bruno, Askiel; Russell, Patrick W.; Jones, William L.; Austin, Jeffrey K.; Weinstein, Eric S.; Steel, Susan R.

In: Stroke, Vol. 23, No. 6, 01.01.1992, p. 900-902.

Research output: Contribution to journalArticle

Bruno, A, Russell, PW, Jones, WL, Austin, JK, Weinstein, ES & Steel, SR 1992, 'Concomitants of asymptomatic retinal cholesterol emboli', Stroke, vol. 23, no. 6, pp. 900-902. https://doi.org/10.1161/01.STR.23.6.900
Bruno A, Russell PW, Jones WL, Austin JK, Weinstein ES, Steel SR. Concomitants of asymptomatic retinal cholesterol emboli. Stroke. 1992 Jan 1;23(6):900-902. https://doi.org/10.1161/01.STR.23.6.900
Bruno, Askiel ; Russell, Patrick W. ; Jones, William L. ; Austin, Jeffrey K. ; Weinstein, Eric S. ; Steel, Susan R. / Concomitants of asymptomatic retinal cholesterol emboli. In: Stroke. 1992 ; Vol. 23, No. 6. pp. 900-902.
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