Abstract
Objective: The objective of the study was to determine the feasibility of weekly carboplatin/paclitaxel with radiation therapy (RT) in the primary treatment of cervical cancer. Study Design: Women diagnosed with stage IB-1 to stage IVA untreated primary cervical cancer were eligible. Carboplatin (area under the curve = 2.0) and paclitaxel 40 mg/m2 were administered weekly for 6 weeks with pelvic RT. Brachytherapy was completed after pelvic RT. Acute toxicities and response to treatment were assessed. Results: Twenty-two evaluable patients were enrolled. The median duration of follow-up was 23 months. Carboplatin (mean dose 245 mg) and paclitaxel (mean dose 70 mg) were successfully administered in 97% and 90% of planned treatments, respectively. Median time to complete external radiation therapy was 36.6 days (25-57 days). Grade 3/4 hematologic or gastrointestinal toxicity was unusual. The complete response rate 3 months after completion of therapy was 91%. The estimated 3-year progression-free survival is 70% and overall survival is 65%. Conclusion: Weekly carboplatin/paclitaxel and RT is a reasonable treatment regimen for cervical cancer.
Original language | English (US) |
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Pages (from-to) | 205.e1-205.e7 |
Journal | American journal of obstetrics and gynecology |
Volume | 197 |
Issue number | 2 |
DOIs | |
State | Published - Aug 2007 |
Externally published | Yes |
Keywords
- carboplatin
- cervical cancer
- paclitaxel
- radiation therapy
- toxicities
ASJC Scopus subject areas
- Obstetrics and Gynecology