Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis

How Does It Affect the Clinical Course and Severity Scores?

Yuchen Wang, Bashar M. Attar, Keiki Hinami, Palashkumar Jaiswal, John Erikson Lim Yap, Radhika Jaiswal, Kalpit Devani, Carlos Roberto Simons-Linares, Melchor V. Demetria

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives Concurrent diabetic ketoacidosis (DKA) is highly prevalent in patients with hypertriglyceridemia-induced pancreatitis (HP). Diabetic ketoacidosis could potentially complicate the diagnosis, management, and prognosis of HP. This study aimed to directly compare the clinical course of HP with and without DKA and assess the outcomes of frequently used severity-prediction scores in such population. Methods We retrospectively analyzed 140 patients with HP; 37 patients (26.4%) had concurrent DKA. We compared epidemiologic characteristics, initial laboratory values, and clinical courses between the DKA and non-DKA groups. Bedside Index for Severity in Acute Pancreatitis score, Sequential Organ Failure Assessment score, Ranson criteria, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Marshall score were calculated and compared between groups. Results We observed more acute kidney injury in the DKA group. Patients with DKA more likely required intensive care unit admission, received intravenous insulin, and were discharged on subcutaneous insulin. Ranson criteria and APACHE II score were significantly higher with DKA. Conclusions Concurrent DKA does not affect length of stay, in-hospital mortality, and readmission rate in patients with HP. Higher Ranson criteria and APACHE II score likely reflected derangement of clinical parameters secondary to DKA rather than true severity of pancreatitis in such population.

Original languageEnglish (US)
Pages (from-to)1336-1340
Number of pages5
JournalPancreas
Volume46
Issue number10
DOIs
StatePublished - Nov 1 2017
Externally publishedYes

Fingerprint

Diabetic Ketoacidosis
Hypertriglyceridemia
Pancreatitis
APACHE
Insulin
Organ Dysfunction Scores
Patient Readmission
Ketosis
Hospital Mortality
Acute Kidney Injury
Population
Intensive Care Units
Length of Stay

Keywords

  • diabetic ketoacidosis
  • hypertriglyceridemia
  • pancreatitis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis : How Does It Affect the Clinical Course and Severity Scores? / Wang, Yuchen; Attar, Bashar M.; Hinami, Keiki; Jaiswal, Palashkumar; Yap, John Erikson Lim; Jaiswal, Radhika; Devani, Kalpit; Simons-Linares, Carlos Roberto; Demetria, Melchor V.

In: Pancreas, Vol. 46, No. 10, 01.11.2017, p. 1336-1340.

Research output: Contribution to journalArticle

Wang, Y, Attar, BM, Hinami, K, Jaiswal, P, Yap, JEL, Jaiswal, R, Devani, K, Simons-Linares, CR & Demetria, MV 2017, 'Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis: How Does It Affect the Clinical Course and Severity Scores?', Pancreas, vol. 46, no. 10, pp. 1336-1340. https://doi.org/10.1097/MPA.0000000000000937
Wang, Yuchen ; Attar, Bashar M. ; Hinami, Keiki ; Jaiswal, Palashkumar ; Yap, John Erikson Lim ; Jaiswal, Radhika ; Devani, Kalpit ; Simons-Linares, Carlos Roberto ; Demetria, Melchor V. / Concurrent Diabetic Ketoacidosis in Hypertriglyceridemia-Induced Pancreatitis : How Does It Affect the Clinical Course and Severity Scores?. In: Pancreas. 2017 ; Vol. 46, No. 10. pp. 1336-1340.
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