Conditioning with rabbit versus horse ATG dramatically alters clinical outcomes in identical twins with severe aplastic anemia transplanted with the same allogeneic donor

P. T. Vo, Jeremy Mark Pantin, C. Ramos, L. Cook, E. Cho, R. Kurlander, H. Khuu, J. Barrett, S. Leitman, R. W. Childs

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Severe aplastic anemia (SAA) is a rare disorder leading to bone marrow failure, which if left untreated, is invariably fatal. Conventional therapies with immunosuppressive therapy or allogeneic hematopoietic stem cell transplantation (HSCT) are highly effective. HSCT can offer a greater outcome in younger patients who have an available HLA match-related donor. Recent studies showing the addition of antithymocyte globulin (ATG) to the conditioning regimen improves engraftment and reduces the risk of graft-versus-host disease (GVHD).There are currently two ATG preparations in the USA, equine (or horse) and rabbit ATG. These agents are pharmacologically distinct, having significant differences in their pharmacokinetics and in vivo immunosuppressive effects [N Engl J Med 365(5):430-438, 2011]. Here, we report a case of two monozygotic twins with constitutional SAA that evolved to myelodysplastic syndrome (MDS) who both underwent allogeneic peripheral blood stem cell transplantation (PBSC) from the same single HLA antigen mismatched sibling donor with the only difference in the transplant regimen being the type of ATG used in the preparative regimen; one twin received horse ATG and the other received rabbit ATG during conditioning. This report emphasizes that dramatic differences in donor T cell chimerism and clinical outcomes including GVHD can occur as a consequence of the type of ATG that is utilized in the transplant conditioning regimen. These differences highlight that these agents should not be considered interchangeable drugs when used in this setting.

Original languageEnglish (US)
Article number78
JournalJournal of Hematology and Oncology
Volume8
Issue number1
DOIs
StatePublished - Jun 26 2015

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Antilymphocyte Serum
Monozygotic Twins
Aplastic Anemia
Horses
Tissue Donors
Rabbits
Hematopoietic Stem Cell Transplantation
Graft vs Host Disease
Immunosuppressive Agents
Transplants
Peripheral Blood Stem Cell Transplantation
Chimerism
Myelodysplastic Syndromes
HLA Antigens
Conditioning (Psychology)
Siblings
Pharmacokinetics
Bone Marrow
T-Lymphocytes
Therapeutics

Keywords

  • Allogeneic bone marrow transplant
  • Identical twins
  • Rabbit versus horse ATG conditioning
  • Severe aplastic anemia

ASJC Scopus subject areas

  • Hematology
  • Molecular Biology
  • Oncology
  • Cancer Research

Cite this

Conditioning with rabbit versus horse ATG dramatically alters clinical outcomes in identical twins with severe aplastic anemia transplanted with the same allogeneic donor. / Vo, P. T.; Pantin, Jeremy Mark; Ramos, C.; Cook, L.; Cho, E.; Kurlander, R.; Khuu, H.; Barrett, J.; Leitman, S.; Childs, R. W.

In: Journal of Hematology and Oncology, Vol. 8, No. 1, 78, 26.06.2015.

Research output: Contribution to journalArticle

Vo, P. T. ; Pantin, Jeremy Mark ; Ramos, C. ; Cook, L. ; Cho, E. ; Kurlander, R. ; Khuu, H. ; Barrett, J. ; Leitman, S. ; Childs, R. W. / Conditioning with rabbit versus horse ATG dramatically alters clinical outcomes in identical twins with severe aplastic anemia transplanted with the same allogeneic donor. In: Journal of Hematology and Oncology. 2015 ; Vol. 8, No. 1.
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