Congener-specific effects of PCBs on contractions of pregnant rat uteri

Mei Ling Tsai, R Clinton Webb, Rita Loch-Caruso

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Both increased and decreased gestation lengths have been reported following exposures to polychlorinated biphenyl (PCB) mixtures and congeners. Because oscillatory uterine contractions are essential for parturition, we hypothesized that the disparate findings on gestation length may be the result of distinct PCB congener-specific actions on oscillatory uterine contractions. This study examined the acute effects of PCB congeners on isometric contractions of isolated pregnant uteri and the structure-activity relationship for individual congeners. After cumulative exposure to individual PCB congeners (0.5 μM to 150 μM), oscillatory contractions were: 1) not altered by 2,4,5,2′,4′,5′-hexachlorobiphenyl, 3,4,5,3′,4′-pentachlorobiphenyl, or 3,4,3′,4′-tetrachlorobiphenyl; 2) significantly inhibited by 4-hydroxy-2′,4′,6′-trichlorobiphenyl; and 3) markedly increased by 2,4,6-trichlorobiphenyl and 2,4,2′,4′-tetrachlorobiphenyl, when compared to solvent controls. The uteri were more sensitive to PCB congeners with ortho-substituted light chlorination than those highly chlorinated, or those interacting with the Ah-receptor.

Original languageEnglish (US)
Pages (from-to)21-28
Number of pages8
JournalReproductive Toxicology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

Keywords

  • Polychlorinated biphenyls
  • Rats
  • Smooth muscle
  • Spontaneous oscillations
  • Uterine contraction
  • Uterus

ASJC Scopus subject areas

  • Toxicology

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