Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population

Dong V. Wang, Joseph Zhuo Tsien

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor- elated motivational signals that are associated with movement initiation, maintenance and termination.

Original languageEnglish (US)
Article numbere16528
JournalPLoS One
Volume6
Issue number1
DOIs
StatePublished - Feb 7 2011

Fingerprint

Ventral Tegmental Area
Neurons
dopamine
neurons
Dopamine
Processing
Population
Dopaminergic Neurons
Running
Motivation
Reward
wheels
Maintenance
Wheels
Animals
Chemical activation
mice
animals

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population. / Wang, Dong V.; Tsien, Joseph Zhuo.

In: PLoS One, Vol. 6, No. 1, e16528, 07.02.2011.

Research output: Contribution to journalArticle

@article{486b670473c24a31b372b919521b79f8,
title = "Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population",
abstract = "The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor- elated motivational signals that are associated with movement initiation, maintenance and termination.",
author = "Wang, {Dong V.} and Tsien, {Joseph Zhuo}",
year = "2011",
month = "2",
day = "7",
doi = "10.1371/journal.pone.0016528",
language = "English (US)",
volume = "6",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

TY - JOUR

T1 - Conjunctive processing of locomotor signals by the ventral tegmental area neuronal population

AU - Wang, Dong V.

AU - Tsien, Joseph Zhuo

PY - 2011/2/7

Y1 - 2011/2/7

N2 - The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor- elated motivational signals that are associated with movement initiation, maintenance and termination.

AB - The ventral tegmental area (VTA) plays an essential role in reward and motivation. How the dopamine (DA) and non-DA neurons in the VTA engage in motivation-based locomotor behaviors is not well understood. We recorded activity of putative DA and non-DA neurons simultaneously in the VTA of awake mice engaged in motivated voluntary movements such as wheel running. Our results revealed that VTA non-DA neurons exhibited significant rhythmic activity that was correlated with the animal's running rhythms. Activity of putative DA neurons also correlated with the movement behavior, but to a lesser degree. More importantly, putative DA neurons exhibited significant burst activation at both onset and offset of voluntary movements. These findings suggest that VTA DA and non-DA neurons conjunctively process locomotor- elated motivational signals that are associated with movement initiation, maintenance and termination.

UR - http://www.scopus.com/inward/record.url?scp=79551559488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551559488&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0016528

DO - 10.1371/journal.pone.0016528

M3 - Article

VL - 6

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 1

M1 - e16528

ER -