Conservative management of pediatric pancreatic pseudocyst using octreotide acetate

C. Mulligan, C. Howell, Robyn M Hatley, R. Martindale, J. Clark

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Pancreatic pseudocysts in children are rare. A total of 213 cases have been reported in the literature, the majority secondary to trauma (65%). Treatment options range from conservative, non-operative management to operative drainage. Octreotide acetate, a long-acting analog of somatostatin, is a synthetic peptide with a variety of endocrine and gastrointestinal functions. Octreotide has been successfully used following pancreatic surgery to reduce exocrine function and most recently in the management of adult pancreatic pseudocysts. We report the efficacy of octreotide, as an adjunct to treatment, in two children with pancreatic pseudocyst. Each child was treated conservatively with bowel rest, hyperalimentation, and octreotide acetate (2.5 μg/kg SQ QD). Complete resolution of the pseudocysts occurred within 5 weeks. We conclude that octreotide acetate is a safe and potentially effective adjunct in the treatment of pediatric pancreatic pseudocyst, and should be added to the management of pseudocyst before drainage procedures.

Original languageEnglish (US)
Pages (from-to)206-209
Number of pages4
JournalAmerican Surgeon
Volume61
Issue number3
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

Pancreatic Pseudocyst
Octreotide
Pediatrics
Drainage
Somatostatin
Therapeutics
Conservative Treatment
Peptides

ASJC Scopus subject areas

  • Surgery

Cite this

Conservative management of pediatric pancreatic pseudocyst using octreotide acetate. / Mulligan, C.; Howell, C.; Hatley, Robyn M; Martindale, R.; Clark, J.

In: American Surgeon, Vol. 61, No. 3, 01.01.1995, p. 206-209.

Research output: Contribution to journalArticle

Mulligan, C. ; Howell, C. ; Hatley, Robyn M ; Martindale, R. ; Clark, J. / Conservative management of pediatric pancreatic pseudocyst using octreotide acetate. In: American Surgeon. 1995 ; Vol. 61, No. 3. pp. 206-209.
@article{97b642f786ea4b3ea92b707f7078a4a9,
title = "Conservative management of pediatric pancreatic pseudocyst using octreotide acetate",
abstract = "Pancreatic pseudocysts in children are rare. A total of 213 cases have been reported in the literature, the majority secondary to trauma (65{\%}). Treatment options range from conservative, non-operative management to operative drainage. Octreotide acetate, a long-acting analog of somatostatin, is a synthetic peptide with a variety of endocrine and gastrointestinal functions. Octreotide has been successfully used following pancreatic surgery to reduce exocrine function and most recently in the management of adult pancreatic pseudocysts. We report the efficacy of octreotide, as an adjunct to treatment, in two children with pancreatic pseudocyst. Each child was treated conservatively with bowel rest, hyperalimentation, and octreotide acetate (2.5 μg/kg SQ QD). Complete resolution of the pseudocysts occurred within 5 weeks. We conclude that octreotide acetate is a safe and potentially effective adjunct in the treatment of pediatric pancreatic pseudocyst, and should be added to the management of pseudocyst before drainage procedures.",
author = "C. Mulligan and C. Howell and Hatley, {Robyn M} and R. Martindale and J. Clark",
year = "1995",
month = "1",
day = "1",
language = "English (US)",
volume = "61",
pages = "206--209",
journal = "Handbook of Behavioral Neuroscience",
issn = "0003-1348",
publisher = "JAI Press",
number = "3",

}

TY - JOUR

T1 - Conservative management of pediatric pancreatic pseudocyst using octreotide acetate

AU - Mulligan, C.

AU - Howell, C.

AU - Hatley, Robyn M

AU - Martindale, R.

AU - Clark, J.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Pancreatic pseudocysts in children are rare. A total of 213 cases have been reported in the literature, the majority secondary to trauma (65%). Treatment options range from conservative, non-operative management to operative drainage. Octreotide acetate, a long-acting analog of somatostatin, is a synthetic peptide with a variety of endocrine and gastrointestinal functions. Octreotide has been successfully used following pancreatic surgery to reduce exocrine function and most recently in the management of adult pancreatic pseudocysts. We report the efficacy of octreotide, as an adjunct to treatment, in two children with pancreatic pseudocyst. Each child was treated conservatively with bowel rest, hyperalimentation, and octreotide acetate (2.5 μg/kg SQ QD). Complete resolution of the pseudocysts occurred within 5 weeks. We conclude that octreotide acetate is a safe and potentially effective adjunct in the treatment of pediatric pancreatic pseudocyst, and should be added to the management of pseudocyst before drainage procedures.

AB - Pancreatic pseudocysts in children are rare. A total of 213 cases have been reported in the literature, the majority secondary to trauma (65%). Treatment options range from conservative, non-operative management to operative drainage. Octreotide acetate, a long-acting analog of somatostatin, is a synthetic peptide with a variety of endocrine and gastrointestinal functions. Octreotide has been successfully used following pancreatic surgery to reduce exocrine function and most recently in the management of adult pancreatic pseudocysts. We report the efficacy of octreotide, as an adjunct to treatment, in two children with pancreatic pseudocyst. Each child was treated conservatively with bowel rest, hyperalimentation, and octreotide acetate (2.5 μg/kg SQ QD). Complete resolution of the pseudocysts occurred within 5 weeks. We conclude that octreotide acetate is a safe and potentially effective adjunct in the treatment of pediatric pancreatic pseudocyst, and should be added to the management of pseudocyst before drainage procedures.

UR - http://www.scopus.com/inward/record.url?scp=0028950432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028950432&partnerID=8YFLogxK

M3 - Article

C2 - 7887530

AN - SCOPUS:0028950432

VL - 61

SP - 206

EP - 209

JO - Handbook of Behavioral Neuroscience

JF - Handbook of Behavioral Neuroscience

SN - 0003-1348

IS - 3

ER -