Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry

Evangelia Katsoulakis, Malcolm D. Mattes, Justin M. Rineer, Thomas Nabhani, Waleed Fouad Mourad, Kwang Choi, David Schreiber

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective To determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.

Methods In a retrospective study, data were analyzed from patients who were diagnosed with stage IA-IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.

Results Data were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1% and 0% in stage IA, grade 1 disease; 2% and 0% in IA, grade 2; 2% and 1% in IA, grade 3; 2% and 0% in IB, grade 1; 3% and 1% in IB, grade 2; 3% and 2% in IB, grade 3; 7% and 3% in IC, grade 1; 8% and 5% in IC, grade 2; 12% and 8% in IC, grade 3; 7% and 3% in IIA, grade 1; 10% and 4% in IIA, grade 2; 10% and 5% in IIA, grade 3; 8% and 4% in IIB, grade 1; 13% and 8% in IIB, grade 2; and 19% and 12% in IIB, grade 3.

Conclusion Incidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10% or higher risk of lymph node involvement and might benefit from aggressive therapy.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume127
Issue number3
DOIs
StatePublished - Dec 1 2014

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Endometrial Neoplasms
Registries
Epidemiology
Lymph Nodes
Neoplasm Metastasis
Incidence
Endometrioid Carcinoma
Retrospective Studies
Therapeutics

Keywords

  • Endometrial cancer Lymph node Metastasis Surveillance
  • Epidemiology
  • and End Results (SEER) registry Staging

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry. / Katsoulakis, Evangelia; Mattes, Malcolm D.; Rineer, Justin M.; Nabhani, Thomas; Mourad, Waleed Fouad; Choi, Kwang; Schreiber, David.

In: International Journal of Gynecology and Obstetrics, Vol. 127, No. 3, 01.12.2014, p. 293-296.

Research output: Contribution to journalArticle

Katsoulakis, Evangelia ; Mattes, Malcolm D. ; Rineer, Justin M. ; Nabhani, Thomas ; Mourad, Waleed Fouad ; Choi, Kwang ; Schreiber, David. / Contemporary analysis of pelvic and para-aortic metastasis in endometrial cancer using the SEER registry. In: International Journal of Gynecology and Obstetrics. 2014 ; Vol. 127, No. 3. pp. 293-296.
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abstract = "Objective To determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.Methods In a retrospective study, data were analyzed from patients who were diagnosed with stage IA-IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.Results Data were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1{\%} and 0{\%} in stage IA, grade 1 disease; 2{\%} and 0{\%} in IA, grade 2; 2{\%} and 1{\%} in IA, grade 3; 2{\%} and 0{\%} in IB, grade 1; 3{\%} and 1{\%} in IB, grade 2; 3{\%} and 2{\%} in IB, grade 3; 7{\%} and 3{\%} in IC, grade 1; 8{\%} and 5{\%} in IC, grade 2; 12{\%} and 8{\%} in IC, grade 3; 7{\%} and 3{\%} in IIA, grade 1; 10{\%} and 4{\%} in IIA, grade 2; 10{\%} and 5{\%} in IIA, grade 3; 8{\%} and 4{\%} in IIB, grade 1; 13{\%} and 8{\%} in IIB, grade 2; and 19{\%} and 12{\%} in IIB, grade 3.Conclusion Incidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10{\%} or higher risk of lymph node involvement and might benefit from aggressive therapy.",
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N2 - Objective To determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.Methods In a retrospective study, data were analyzed from patients who were diagnosed with stage IA-IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.Results Data were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1% and 0% in stage IA, grade 1 disease; 2% and 0% in IA, grade 2; 2% and 1% in IA, grade 3; 2% and 0% in IB, grade 1; 3% and 1% in IB, grade 2; 3% and 2% in IB, grade 3; 7% and 3% in IC, grade 1; 8% and 5% in IC, grade 2; 12% and 8% in IC, grade 3; 7% and 3% in IIA, grade 1; 10% and 4% in IIA, grade 2; 10% and 5% in IIA, grade 3; 8% and 4% in IIB, grade 1; 13% and 8% in IIB, grade 2; and 19% and 12% in IIB, grade 3.Conclusion Incidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10% or higher risk of lymph node involvement and might benefit from aggressive therapy.

AB - Objective To determine the incidence of regional lymph node involvement for early-stage endometrial cancer by using the Surveillance, Epidemiology, and End Results (SEER) registry.Methods In a retrospective study, data were analyzed from patients who were diagnosed with stage IA-IIB endometrioid adenocarcinoma and were treated between 1998 and 2003. The incidence of pelvic and para-aortic lymph node involvement was determined.Results Data were analyzed from 4052 patients. Incidences of pelvic and para-aortic lymph node metastases were: 1% and 0% in stage IA, grade 1 disease; 2% and 0% in IA, grade 2; 2% and 1% in IA, grade 3; 2% and 0% in IB, grade 1; 3% and 1% in IB, grade 2; 3% and 2% in IB, grade 3; 7% and 3% in IC, grade 1; 8% and 5% in IC, grade 2; 12% and 8% in IC, grade 3; 7% and 3% in IIA, grade 1; 10% and 4% in IIA, grade 2; 10% and 5% in IIA, grade 3; 8% and 4% in IIB, grade 1; 13% and 8% in IIB, grade 2; and 19% and 12% in IIB, grade 3.Conclusion Incidences of pelvic and para-aortic metastases were lower than previously reported. Patients at higher stages and grades had a 10% or higher risk of lymph node involvement and might benefit from aggressive therapy.

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