Contemporary Trends and Outcomes of Percutaneous and Surgical Aortic Valve Replacement in Patients With Cancer

Avirup Guha, Amit K. Dey, Sameer Arora, Matthew A. Cavender, John P. Vavalle, Joseph F. Sabik, Ernesto Jimenez, Hani Jneid, Daniel Addison

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Patients with cancer and severe aortic stenosis are often ineligible for surgical aortic valve replacement (SAVR). Patients with cancer may likely benefit from emerging transcatheter aortic valve replacement (TAVR), given its minimally invasive nature. Methods and Results: The US-based National Inpatient Sample was queried between 2012 and 2015 using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), codes to identify all hospitalized adults (aged ≥50 years), who had a primary diagnosis of aortic stenosis. We examined the effect modification of cancer on the relative use rate, outcomes, and dispositions associated with propensity-matched cohort TAVR versus SAVR. Overall, 47 295 TAVRs (22.6% comorbid cancer) and 113 405 SAVRs (15.2% comorbid cancer) were performed among admissions with aortic stenosis between 2012 and 2015. In the year 2015, patients with cancer saw relatively higher rates of TAVR use compared with SAVR (relative use rateTAVR versus relative use rateSAVR, 67.8% versus 57.2%; P
Original languageEnglish (US)
JournalJournal of the American Heart Association
Volume9
Issue number2
DOIs
StatePublished - Jan 21 2020

Keywords

  • aortic valve replacement
  • epidemiology
  • oncology
  • transcatheter aortic valve

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