Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes

Michael Peter Diamond, Sheron L. Salyer, William K. Vaughn, Robert B. Cotton, Stephen S. Entman, Frank H. Boehm

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Despite having implemented rigorous glucose control for women with gestational diabetes early in the third trimester, we found excessive morbidity among the neonates of these women. To accurately assess the risk of newborn complications, we did a five-year review (1977 to 1981) of infants of class A diabetic mothers to determine the incidence and scope of morbidity in these infants. Fifty-one infants of class A mothers were identified (group 1) and randomly matched with 102 infants of nondiabetic mothers (group 2). The distribution of morbidity between the two groups was as follows: Hypoglycemia 9/51 (18%) vs 0/102 (P <.001); birth injuries 4/51 (8%) vs 1/102 (2%) (P <.05); pulmonary edema 3/51 (6%) vs 0/102 (P <.05); respiratory distress 4/51 (8%) vs 7/102 (7%) (NS); macrosomia 18/51 (35%) vs 23/102 (23%) (NS); and hyperbilirubinemia 3/51 (6%) vs 8/102 (8%) (NS). There were two fetal deaths and three infants with major congenital anomalies among the diabetic pregnancies compared to none from the nondiabetic pregnancies. Compared to insulin-dependent diabetes, class A diabetes is accompanied by relatively mild metabolic disturbances in the mother. On the other hand, the infant of a mother with class A diabetes appears to be at risk for serious and life-threatening complications, both before and after birth. These results raise the question of whether earlier identification, subsequent meticulous diabetic management, and altered timing of delivery might reduce the complications experienced by these infants.

Original languageEnglish (US)
Pages (from-to)1386-1388
Number of pages3
JournalSouthern Medical Journal
Volume77
Issue number11
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Glass
Morbidity
Mothers
Birth Injuries
Newborn Infant
Pregnancy
Hyperbilirubinemia
Fetal Death
Gestational Diabetes
Third Pregnancy Trimester
Pulmonary Edema
Hypoglycemia
Parturition
Insulin
Glucose
Incidence
5-nitro-6,7,8,9-tetrahydrobenzo(G)indole-2,3-dione-3-oxime

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Diamond, M. P., Salyer, S. L., Vaughn, W. K., Cotton, R. B., Entman, S. S., & Boehm, F. H. (1984). Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes. Southern Medical Journal, 77(11), 1386-1388. https://doi.org/10.1097/00007611-198411000-00009

Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes. / Diamond, Michael Peter; Salyer, Sheron L.; Vaughn, William K.; Cotton, Robert B.; Entman, Stephen S.; Boehm, Frank H.

In: Southern Medical Journal, Vol. 77, No. 11, 01.01.1984, p. 1386-1388.

Research output: Contribution to journalArticle

Diamond, MP, Salyer, SL, Vaughn, WK, Cotton, RB, Entman, SS & Boehm, FH 1984, 'Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes', Southern Medical Journal, vol. 77, no. 11, pp. 1386-1388. https://doi.org/10.1097/00007611-198411000-00009
Diamond, Michael Peter ; Salyer, Sheron L. ; Vaughn, William K. ; Cotton, Robert B. ; Entman, Stephen S. ; Boehm, Frank H. / Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes. In: Southern Medical Journal. 1984 ; Vol. 77, No. 11. pp. 1386-1388.
@article{539c49e202c840589af55ed63622c4fd,
title = "Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes",
abstract = "Despite having implemented rigorous glucose control for women with gestational diabetes early in the third trimester, we found excessive morbidity among the neonates of these women. To accurately assess the risk of newborn complications, we did a five-year review (1977 to 1981) of infants of class A diabetic mothers to determine the incidence and scope of morbidity in these infants. Fifty-one infants of class A mothers were identified (group 1) and randomly matched with 102 infants of nondiabetic mothers (group 2). The distribution of morbidity between the two groups was as follows: Hypoglycemia 9/51 (18{\%}) vs 0/102 (P <.001); birth injuries 4/51 (8{\%}) vs 1/102 (2{\%}) (P <.05); pulmonary edema 3/51 (6{\%}) vs 0/102 (P <.05); respiratory distress 4/51 (8{\%}) vs 7/102 (7{\%}) (NS); macrosomia 18/51 (35{\%}) vs 23/102 (23{\%}) (NS); and hyperbilirubinemia 3/51 (6{\%}) vs 8/102 (8{\%}) (NS). There were two fetal deaths and three infants with major congenital anomalies among the diabetic pregnancies compared to none from the nondiabetic pregnancies. Compared to insulin-dependent diabetes, class A diabetes is accompanied by relatively mild metabolic disturbances in the mother. On the other hand, the infant of a mother with class A diabetes appears to be at risk for serious and life-threatening complications, both before and after birth. These results raise the question of whether earlier identification, subsequent meticulous diabetic management, and altered timing of delivery might reduce the complications experienced by these infants.",
author = "Diamond, {Michael Peter} and Salyer, {Sheron L.} and Vaughn, {William K.} and Cotton, {Robert B.} and Entman, {Stephen S.} and Boehm, {Frank H.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1097/00007611-198411000-00009",
language = "English (US)",
volume = "77",
pages = "1386--1388",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Continuing Neonatal Morbidity in Infants of Women with Glass a Diabetes

AU - Diamond, Michael Peter

AU - Salyer, Sheron L.

AU - Vaughn, William K.

AU - Cotton, Robert B.

AU - Entman, Stephen S.

AU - Boehm, Frank H.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Despite having implemented rigorous glucose control for women with gestational diabetes early in the third trimester, we found excessive morbidity among the neonates of these women. To accurately assess the risk of newborn complications, we did a five-year review (1977 to 1981) of infants of class A diabetic mothers to determine the incidence and scope of morbidity in these infants. Fifty-one infants of class A mothers were identified (group 1) and randomly matched with 102 infants of nondiabetic mothers (group 2). The distribution of morbidity between the two groups was as follows: Hypoglycemia 9/51 (18%) vs 0/102 (P <.001); birth injuries 4/51 (8%) vs 1/102 (2%) (P <.05); pulmonary edema 3/51 (6%) vs 0/102 (P <.05); respiratory distress 4/51 (8%) vs 7/102 (7%) (NS); macrosomia 18/51 (35%) vs 23/102 (23%) (NS); and hyperbilirubinemia 3/51 (6%) vs 8/102 (8%) (NS). There were two fetal deaths and three infants with major congenital anomalies among the diabetic pregnancies compared to none from the nondiabetic pregnancies. Compared to insulin-dependent diabetes, class A diabetes is accompanied by relatively mild metabolic disturbances in the mother. On the other hand, the infant of a mother with class A diabetes appears to be at risk for serious and life-threatening complications, both before and after birth. These results raise the question of whether earlier identification, subsequent meticulous diabetic management, and altered timing of delivery might reduce the complications experienced by these infants.

AB - Despite having implemented rigorous glucose control for women with gestational diabetes early in the third trimester, we found excessive morbidity among the neonates of these women. To accurately assess the risk of newborn complications, we did a five-year review (1977 to 1981) of infants of class A diabetic mothers to determine the incidence and scope of morbidity in these infants. Fifty-one infants of class A mothers were identified (group 1) and randomly matched with 102 infants of nondiabetic mothers (group 2). The distribution of morbidity between the two groups was as follows: Hypoglycemia 9/51 (18%) vs 0/102 (P <.001); birth injuries 4/51 (8%) vs 1/102 (2%) (P <.05); pulmonary edema 3/51 (6%) vs 0/102 (P <.05); respiratory distress 4/51 (8%) vs 7/102 (7%) (NS); macrosomia 18/51 (35%) vs 23/102 (23%) (NS); and hyperbilirubinemia 3/51 (6%) vs 8/102 (8%) (NS). There were two fetal deaths and three infants with major congenital anomalies among the diabetic pregnancies compared to none from the nondiabetic pregnancies. Compared to insulin-dependent diabetes, class A diabetes is accompanied by relatively mild metabolic disturbances in the mother. On the other hand, the infant of a mother with class A diabetes appears to be at risk for serious and life-threatening complications, both before and after birth. These results raise the question of whether earlier identification, subsequent meticulous diabetic management, and altered timing of delivery might reduce the complications experienced by these infants.

UR - http://www.scopus.com/inward/record.url?scp=0021748328&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021748328&partnerID=8YFLogxK

U2 - 10.1097/00007611-198411000-00009

DO - 10.1097/00007611-198411000-00009

M3 - Article

VL - 77

SP - 1386

EP - 1388

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 11

ER -