Contractile responses to ouabain and potassium-free solution in vascular tissue from renal hypertensive rats

J. Hurley Myers, Fred S. Lamb, R. Clinton Webb

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

This study characterizes contractions to ouabain and potassium-free solution in isolated vascular segments from two-kidney, one clip (2-K, 1C) hypertensive rats. Aorta, mesenteric artery, and vena cava from hypertensive rats were more sensitive (lower threshold) to ouabain than those from normotensive rats. Contractions of hypertensive vascular segments to potassium-free solution and to ouabain (10−3 mol/l) were faster than those in normotensive vessels. Monensin potentiated contractions to ouabain and increased the rate of force development to potassium-free solution to a greater extent in normotensive aortae than in hypertensive aortae. Amiloride, low sodium solution, verapamil and calcium-free solution depressed contractions to ouabain and potassium-free solution in both hypertensive and normotensive aortae. These observations demonstrate augmented responsiveness to ouabain and potassium-free solution in hypertensive blood vessels. Interventions which influence transmembrane sodium and calcium movements altered contractions to ouabain and potassium-free solution. The results are consistent with the hypothesis that vascular cells of hypertensive rats have enhanced sodium pump activity.

Original languageEnglish (US)
Pages (from-to)161-171
Number of pages11
JournalJournal of hypertension
Volume5
Issue number2
DOIs
StatePublished - Apr 1987

Keywords

  • Arteries
  • Electrogenic sodium pump
  • Vascular smooth muscle
  • Veins

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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