Contribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum

Dan dan Pei, Jin long Sun, Chun hui Zhu, Fucong Tian, Kai Jiao, Matthew R. Anderson, Cynthia Yiu, Cui Huang, Chang xiong Jin, Brian Edward Bergeron, Ji hua Chen, Franklin Chi Meng Tay, Li na Niu

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Biomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it is well established that ACP precursors are released from intracellular vesicles through exocytosis, an unsolved enigma in this cell-mediated mineralization process is how ACP precursors, initially produced in the mitochondria, are translocated to the intracellular vesicles. The present study proposes that mitophagy provides the mechanism for transfer of ACP precursors from the dysfunctioned mitochondria to autophagosomes, which, upon fusion with lysosomes, become autolysosomes where the mitochondrial ACP precursors coalesce to form larger intravesicular granules, prior to their release into the extracellular matrix. Apart from endowing the mitochondria with the function of ACP delivery through mitophagy, the present results indicate that mitophagy, triggered upon intramitochondrial ACP accumulation in osteogenic lineage-committed mesenchymal stem cells, participates in the biomineralization process through the BMP/Smad signaling pathway.

Original languageEnglish (US)
Article number1800873
JournalAdvanced Science
Volume5
Issue number10
DOIs
StatePublished - Oct 1 2018

Fingerprint

Mitochondrial Degradation
calcium phosphates
Calcium phosphate
Mitochondria
mitochondria
cells
Biomineralization
Extracellular Matrix
lysosomes
Apatites
vertebrates
stem cells
Exocytosis
Apatite
apatites
collagens
matrices
Lysosomes
amorphous calcium phosphate
Stem cells

Keywords

  • amorphous calcium phosphate
  • mineralization
  • mitophagy
  • osteogenesis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Pei, D. D., Sun, J. L., Zhu, C. H., Tian, F., Jiao, K., Anderson, M. R., ... Niu, L. N. (2018). Contribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum. Advanced Science, 5(10), [1800873]. https://doi.org/10.1002/advs.201800873

Contribution of Mitophagy to Cell-Mediated Mineralization : Revisiting a 50-Year-Old Conundrum. / Pei, Dan dan; Sun, Jin long; Zhu, Chun hui; Tian, Fucong; Jiao, Kai; Anderson, Matthew R.; Yiu, Cynthia; Huang, Cui; Jin, Chang xiong; Bergeron, Brian Edward; Chen, Ji hua; Tay, Franklin Chi Meng; Niu, Li na.

In: Advanced Science, Vol. 5, No. 10, 1800873, 01.10.2018.

Research output: Contribution to journalArticle

Pei, DD, Sun, JL, Zhu, CH, Tian, F, Jiao, K, Anderson, MR, Yiu, C, Huang, C, Jin, CX, Bergeron, BE, Chen, JH, Tay, FCM & Niu, LN 2018, 'Contribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum', Advanced Science, vol. 5, no. 10, 1800873. https://doi.org/10.1002/advs.201800873
Pei, Dan dan ; Sun, Jin long ; Zhu, Chun hui ; Tian, Fucong ; Jiao, Kai ; Anderson, Matthew R. ; Yiu, Cynthia ; Huang, Cui ; Jin, Chang xiong ; Bergeron, Brian Edward ; Chen, Ji hua ; Tay, Franklin Chi Meng ; Niu, Li na. / Contribution of Mitophagy to Cell-Mediated Mineralization : Revisiting a 50-Year-Old Conundrum. In: Advanced Science. 2018 ; Vol. 5, No. 10.
@article{9dd2fc6ea3ae4f8c8411a9f6e0fe50b8,
title = "Contribution of Mitophagy to Cell-Mediated Mineralization: Revisiting a 50-Year-Old Conundrum",
abstract = "Biomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it is well established that ACP precursors are released from intracellular vesicles through exocytosis, an unsolved enigma in this cell-mediated mineralization process is how ACP precursors, initially produced in the mitochondria, are translocated to the intracellular vesicles. The present study proposes that mitophagy provides the mechanism for transfer of ACP precursors from the dysfunctioned mitochondria to autophagosomes, which, upon fusion with lysosomes, become autolysosomes where the mitochondrial ACP precursors coalesce to form larger intravesicular granules, prior to their release into the extracellular matrix. Apart from endowing the mitochondria with the function of ACP delivery through mitophagy, the present results indicate that mitophagy, triggered upon intramitochondrial ACP accumulation in osteogenic lineage-committed mesenchymal stem cells, participates in the biomineralization process through the BMP/Smad signaling pathway.",
keywords = "amorphous calcium phosphate, mineralization, mitophagy, osteogenesis",
author = "Pei, {Dan dan} and Sun, {Jin long} and Zhu, {Chun hui} and Fucong Tian and Kai Jiao and Anderson, {Matthew R.} and Cynthia Yiu and Cui Huang and Jin, {Chang xiong} and Bergeron, {Brian Edward} and Chen, {Ji hua} and Tay, {Franklin Chi Meng} and Niu, {Li na}",
year = "2018",
month = "10",
day = "1",
doi = "10.1002/advs.201800873",
language = "English (US)",
volume = "5",
journal = "Advanced Science",
issn = "2198-3844",
publisher = "Wiley-VCH Verlag",
number = "10",

}

TY - JOUR

T1 - Contribution of Mitophagy to Cell-Mediated Mineralization

T2 - Revisiting a 50-Year-Old Conundrum

AU - Pei, Dan dan

AU - Sun, Jin long

AU - Zhu, Chun hui

AU - Tian, Fucong

AU - Jiao, Kai

AU - Anderson, Matthew R.

AU - Yiu, Cynthia

AU - Huang, Cui

AU - Jin, Chang xiong

AU - Bergeron, Brian Edward

AU - Chen, Ji hua

AU - Tay, Franklin Chi Meng

AU - Niu, Li na

PY - 2018/10/1

Y1 - 2018/10/1

N2 - Biomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it is well established that ACP precursors are released from intracellular vesicles through exocytosis, an unsolved enigma in this cell-mediated mineralization process is how ACP precursors, initially produced in the mitochondria, are translocated to the intracellular vesicles. The present study proposes that mitophagy provides the mechanism for transfer of ACP precursors from the dysfunctioned mitochondria to autophagosomes, which, upon fusion with lysosomes, become autolysosomes where the mitochondrial ACP precursors coalesce to form larger intravesicular granules, prior to their release into the extracellular matrix. Apart from endowing the mitochondria with the function of ACP delivery through mitophagy, the present results indicate that mitophagy, triggered upon intramitochondrial ACP accumulation in osteogenic lineage-committed mesenchymal stem cells, participates in the biomineralization process through the BMP/Smad signaling pathway.

AB - Biomineralization in vertebrates is initiated via amorphous calcium phosphate (ACP) precursors. These precursors infiltrate the extracellular collagen matrix where they undergo phase transformation into intrafibrillar carbonated apatite. Although it is well established that ACP precursors are released from intracellular vesicles through exocytosis, an unsolved enigma in this cell-mediated mineralization process is how ACP precursors, initially produced in the mitochondria, are translocated to the intracellular vesicles. The present study proposes that mitophagy provides the mechanism for transfer of ACP precursors from the dysfunctioned mitochondria to autophagosomes, which, upon fusion with lysosomes, become autolysosomes where the mitochondrial ACP precursors coalesce to form larger intravesicular granules, prior to their release into the extracellular matrix. Apart from endowing the mitochondria with the function of ACP delivery through mitophagy, the present results indicate that mitophagy, triggered upon intramitochondrial ACP accumulation in osteogenic lineage-committed mesenchymal stem cells, participates in the biomineralization process through the BMP/Smad signaling pathway.

KW - amorphous calcium phosphate

KW - mineralization

KW - mitophagy

KW - osteogenesis

UR - http://www.scopus.com/inward/record.url?scp=85051066696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85051066696&partnerID=8YFLogxK

U2 - 10.1002/advs.201800873

DO - 10.1002/advs.201800873

M3 - Article

AN - SCOPUS:85051066696

VL - 5

JO - Advanced Science

JF - Advanced Science

SN - 2198-3844

IS - 10

M1 - 1800873

ER -