Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior

Ansong Ping, Jinlei Xi, Balakrishna M. Prasad, Mong-Heng Wang, Paul J. Kruzich

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Glutamate signaling in the nucleus accumbens influences reinstatement of previously extinguished cocaine-seeking behavior in rats. Whether or not region specific glutamate signaling in the nucleus accumbens contributes to reinstatement of cocaine-seeking behavior is not known. We investigated whether directly stimulating ionotropic glutamate receptors (GluRs) within the nucleus accumbens core or shell would differentially influence renewed cocaine-seeking behavior following extinction training. We also tested the hypothesis that GluR1 subunit (GluR1) containing alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMPA) receptors in the nucleus accumbens core and not the shell regulate reinstatement of previously extinguished cocaine-seeking behavior. Microinjection of AMPA into the nucleus accumbens shell and the nucleus accumbens core dose-dependently elicited significant cocaine-seeking behavior. Administration of antisense oligonucleotides (AS) directed against GluR1 subunit mRNA into the core and shell disrupted AMPA- and cocaine-primed reinstatement-with the most pronounced effects seen in the nucleus accumbens shell. These results demonstrate that GluRs in the nucleus accumbens core and shell influence AMPA- and cocaine-primed reinstatement, yet the nucleus accumbens shell exerts a prepotency over the nucleus accumbens core.

Original languageEnglish (US)
Pages (from-to)173-182
Number of pages10
JournalBrain Research
Volume1215
DOIs
StatePublished - Jun 18 2008

Fingerprint

Amino Acid Receptors
Nucleus Accumbens
Cocaine
Acids
Glutamic Acid
bucide
Ionotropic Glutamate Receptors
Antisense Oligonucleotides
Glutamate Receptors
Microinjections

Keywords

  • AMPA
  • Extinction
  • GluR1
  • Intracranial
  • Rat
  • Relapse
  • Self-administration

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Contributions of nucleus accumbens core and shell GluR1 containing AMPA receptors in AMPA- and cocaine-primed reinstatement of cocaine-seeking behavior. / Ping, Ansong; Xi, Jinlei; Prasad, Balakrishna M.; Wang, Mong-Heng; Kruzich, Paul J.

In: Brain Research, Vol. 1215, 18.06.2008, p. 173-182.

Research output: Contribution to journalArticle

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