Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin

Mykola Mamenko, Oleg Zaika, Nabila Boukelmoune, Eric Madden, Oleh Pochynyuk

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Kinins, such as Bradykinin (BK), are peptide hormones of the kallikrein-kinin system. Apart from being a vasodilator, BK also increases urinary sodium excretion to reduce systemic blood pressure. It is becoming appreciated that BK modulates function of the epithelial Na+ channel in the distal part of the renal nephron to affect tubular sodium reabsorption. In this chapter, we outline the molecular details, as well as discuss the physiological relevance of this regulation for the whole organism sodium homeostasis and setting chronic blood pressure.

Original languageEnglish (US)
Title of host publicationVitamins and Hormones
PublisherAcademic Press Inc.
Pages137-154
Number of pages18
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Publication series

NameVitamins and Hormones
Volume98
ISSN (Print)0083-6729

Fingerprint

Nephrons
Bradykinin
Sodium
Kallikrein-Kinin System
Blood Pressure
Epithelial Sodium Channels
Kinins
Peptide Hormones
Vasodilator Agents
Homeostasis
Kidney

Keywords

  • ACE inhibition
  • Blood pressure
  • Kidney
  • Natriuresis
  • Renal tubule
  • Salt sensitivity

ASJC Scopus subject areas

  • Physiology
  • Endocrinology

Cite this

Mamenko, M., Zaika, O., Boukelmoune, N., Madden, E., & Pochynyuk, O. (2015). Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin. In Vitamins and Hormones (pp. 137-154). (Vitamins and Hormones; Vol. 98). Academic Press Inc.. https://doi.org/10.1016/bs.vh.2014.12.005

Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin. / Mamenko, Mykola; Zaika, Oleg; Boukelmoune, Nabila; Madden, Eric; Pochynyuk, Oleh.

Vitamins and Hormones. Academic Press Inc., 2015. p. 137-154 (Vitamins and Hormones; Vol. 98).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mamenko, M, Zaika, O, Boukelmoune, N, Madden, E & Pochynyuk, O 2015, Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin. in Vitamins and Hormones. Vitamins and Hormones, vol. 98, Academic Press Inc., pp. 137-154. https://doi.org/10.1016/bs.vh.2014.12.005
Mamenko M, Zaika O, Boukelmoune N, Madden E, Pochynyuk O. Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin. In Vitamins and Hormones. Academic Press Inc. 2015. p. 137-154. (Vitamins and Hormones). https://doi.org/10.1016/bs.vh.2014.12.005
Mamenko, Mykola ; Zaika, Oleg ; Boukelmoune, Nabila ; Madden, Eric ; Pochynyuk, Oleh. / Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin. Vitamins and Hormones. Academic Press Inc., 2015. pp. 137-154 (Vitamins and Hormones).
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