Coping with the inevitable: How cells repair a torn surface membrane

Paul L McNeil, Mark Terasaki

Research output: Contribution to journalReview article

135 Citations (Scopus)

Abstract

Disruption of the cell plasma membrane is a commonplace occurrence in many mechanically challenging, biological environments. 'Resealing' is the emergency response required for cell survival. Resealing is triggered by Ca2+ entering through the disruption; this causes vesicles present in cytoplasm underlying the disruption site to fuse rapidly with one another (homotypically) and also with the adjacent plasma membrane (heterotypically/exocytotically). The large vesicular products of homotypic fusion are added as a reparative 'patch' across the disruption, when its resealing requires membrane replacement. The simultaneous activation of the local cytoskeleton supports these membrane fusion events. Resealing is clearly a complex and dynamic cell adaptation, and, and as we emphasize here, may be an evolutionarily primitive one that arose shortly after the ancestral eukaryote lost its protective cell wall.

Original languageEnglish (US)
JournalNature Cell Biology
Volume3
Issue number5
DOIs
StatePublished - May 21 2001

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Cell Membrane
Membranes
Membrane Fusion
Eukaryota
Cytoskeleton
Cell Wall
Cell Survival
Cytoplasm
Emergencies

ASJC Scopus subject areas

  • Cell Biology

Cite this

Coping with the inevitable : How cells repair a torn surface membrane. / McNeil, Paul L; Terasaki, Mark.

In: Nature Cell Biology, Vol. 3, No. 5, 21.05.2001.

Research output: Contribution to journalReview article

McNeil, Paul L ; Terasaki, Mark. / Coping with the inevitable : How cells repair a torn surface membrane. In: Nature Cell Biology. 2001 ; Vol. 3, No. 5.
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