Copper transporters and copper chaperones

Roles in cardiovascular physiology and disease

Tohru Fukai, Masuko Fukai, Jack H. Kaplan

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Copper (Cu) is an essential micronutrient but excess Cu is potentially toxic. Its important propensity to cycle between two oxidation states accounts for its frequent presence as a cofactor in many physiological processes through Cucontaining enzymes, including mitochondrial energy production (via cytochrome c-oxidase), protection against oxidative stress (via superoxide dismutase), and extracellular matrix stability (via lysyl oxidase). Since free Cu is potentially toxic, the bioavailability of intracellular Cu is tightly controlled by Cu transporters and Cu chaperones. Recent evidence reveals that these Cu transport systems play an essential role in the physiological responses of cardiovascular cells, including cell growth, migration, angiogenesis and wound repair. In response to growth factors, cytokines, and hypoxia, their expression, subcellular localization, and function are tightly regulated. Cu transport systems and their regulators have also been linked to various cardiovascular pathophysiologies such as hypertension, inflammation, atherosclerosis, diabetes, cardiac hypertrophy, and cardiomyopathy. A greater appreciation of the central importance of Cu transporters and Cu chaperones in cell signaling and gene expression in cardiovascular biology offers the possibility of identifying new therapeutic targets for cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)C186-C201
JournalAmerican Journal of Physiology - Cell Physiology
Volume315
Issue number2
DOIs
StatePublished - Aug 1 2018

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Cardiovascular Physiological Phenomena
Poisons
Copper
Cardiovascular Diseases
Protein-Lysine 6-Oxidase
Physiological Phenomena
Micronutrients
Cardiomegaly
Electron Transport Complex IV
Cardiomyopathies
Biological Availability
Superoxide Dismutase
Cell Movement
Extracellular Matrix
Atherosclerosis
Intercellular Signaling Peptides and Proteins
Oxidative Stress
Cytokines
Hypertension
Inflammation

Keywords

  • Cardiovascular diseases
  • Copper chaperones
  • Copper homeostasis
  • Copper transporters
  • Vascular physiology

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

Copper transporters and copper chaperones : Roles in cardiovascular physiology and disease. / Fukai, Tohru; Fukai, Masuko; Kaplan, Jack H.

In: American Journal of Physiology - Cell Physiology, Vol. 315, No. 2, 01.08.2018, p. C186-C201.

Research output: Contribution to journalReview article

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