Cord blood endothelial progenitor cells as therapeutic and imaging probes

Branislava Janic, Ali Syed Arbab

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Numerous studies demonstrated that neovascularization processes associated with severe tissue ischemia commonly found in conditions such as cardiovascular disorders and tumor growth occur via angiogenic and vasculogenic mechanisms. Over the past decade, it has been demonstrated that endothelial progenitor cells (EPCs) play a significant role in neo-angiogenic and neovasculogenic processes. Due to their ability to self-renew, circulate, home to the ischemic sites and differentiate into mature endothelial cells, EPCs derived from various sources hold enormous potential to be used as therapeutic agents in pro- or anti-angiogenic strategies for the treatment of ischemic and tumor conditions, respectively. However, the development of EPC-based therapies requires accompanying, noninvasive imaging protocol for in vivo tracking of transplanted cells. Hence, this review focuses on cord blood-derived EPCs and their role in neovascularization with emphasis on the potential use of EPCs as a therapeutic and imaging probe.

Original languageEnglish (US)
Pages (from-to)477-490
Number of pages14
JournalImaging in Medicine
Volume4
Issue number4
DOIs
StatePublished - Aug 1 2012
Externally publishedYes

Fingerprint

Fetal Blood
Blood Cells
Cell Tracking
Growth Disorders
Therapeutics
Cell- and Tissue-Based Therapy
Neoplasms
Ischemia
Endothelial Cells
Endothelial Progenitor Cells

Keywords

  • angiogenesis
  • cord blood
  • endothelial progenitor cells
  • imaging probe
  • vasculogenesis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Cord blood endothelial progenitor cells as therapeutic and imaging probes. / Janic, Branislava; Arbab, Ali Syed.

In: Imaging in Medicine, Vol. 4, No. 4, 01.08.2012, p. 477-490.

Research output: Contribution to journalReview article

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