Corpus callosotomy for the treatment of intractable epilepsy in children

George S. Makari, Gregory L. Holmes, Anthony M Murro, Joseph R. Smith, Herman F. Flanigin, Morris J. Cohen, Kyoon Huh, Brian S. Gallagher, Adele B. Ackell, Rebecca Campbell, Don W. King

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We report the results of anterior two-thirds corpus callosotomies in 20 children undergoing the procedure for intractable seizures. All children recovered from the callosotomy without significant neurological sequelae. Excellent results with regard to seizure frequency were found in 8 of 20 (40%) patients. Following surgery, generalized tonic-clonic seizures, tonic seizures, and atonic seizures were reduced from their preoperative frequency. Although all patients in the postoperative period continued on antiepileptic drugs, there was a significant reduction in the number of drugs used. There was no statistically significant relationship between outcome and age of onset of the seizures, presence or absence of mental retardation, computerized tomography or magnetic resonance imaging findings, presence of hemiplegia, and preoperative EEG abnormalities. Although anterior two-thirds corpus callosotomy may be valuable in reducing seizure frequency in some children, it is currently not possible to predict accurately which children will benefit from the procedure.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalJournal of Epilepsy
Volume2
Issue number1
DOIs
StatePublished - 1989

Fingerprint

Seizures
Therapeutics
Hemiplegia
Drug Resistant Epilepsy
Age of Onset
Postoperative Period
Intellectual Disability
Anticonvulsants
Electroencephalography
Tomography
Magnetic Resonance Imaging
Pharmaceutical Preparations

Keywords

  • Corpus callosum
  • Epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Makari, G. S., Holmes, G. L., Murro, A. M., Smith, J. R., Flanigin, H. F., Cohen, M. J., ... King, D. W. (1989). Corpus callosotomy for the treatment of intractable epilepsy in children. Journal of Epilepsy, 2(1), 1-7. https://doi.org/10.1016/0896-6974(89)90052-2

Corpus callosotomy for the treatment of intractable epilepsy in children. / Makari, George S.; Holmes, Gregory L.; Murro, Anthony M; Smith, Joseph R.; Flanigin, Herman F.; Cohen, Morris J.; Huh, Kyoon; Gallagher, Brian S.; Ackell, Adele B.; Campbell, Rebecca; King, Don W.

In: Journal of Epilepsy, Vol. 2, No. 1, 1989, p. 1-7.

Research output: Contribution to journalArticle

Makari, GS, Holmes, GL, Murro, AM, Smith, JR, Flanigin, HF, Cohen, MJ, Huh, K, Gallagher, BS, Ackell, AB, Campbell, R & King, DW 1989, 'Corpus callosotomy for the treatment of intractable epilepsy in children', Journal of Epilepsy, vol. 2, no. 1, pp. 1-7. https://doi.org/10.1016/0896-6974(89)90052-2
Makari, George S. ; Holmes, Gregory L. ; Murro, Anthony M ; Smith, Joseph R. ; Flanigin, Herman F. ; Cohen, Morris J. ; Huh, Kyoon ; Gallagher, Brian S. ; Ackell, Adele B. ; Campbell, Rebecca ; King, Don W. / Corpus callosotomy for the treatment of intractable epilepsy in children. In: Journal of Epilepsy. 1989 ; Vol. 2, No. 1. pp. 1-7.
@article{cb74ff5852874b01b1801514bc7e2d1e,
title = "Corpus callosotomy for the treatment of intractable epilepsy in children",
abstract = "We report the results of anterior two-thirds corpus callosotomies in 20 children undergoing the procedure for intractable seizures. All children recovered from the callosotomy without significant neurological sequelae. Excellent results with regard to seizure frequency were found in 8 of 20 (40{\%}) patients. Following surgery, generalized tonic-clonic seizures, tonic seizures, and atonic seizures were reduced from their preoperative frequency. Although all patients in the postoperative period continued on antiepileptic drugs, there was a significant reduction in the number of drugs used. There was no statistically significant relationship between outcome and age of onset of the seizures, presence or absence of mental retardation, computerized tomography or magnetic resonance imaging findings, presence of hemiplegia, and preoperative EEG abnormalities. Although anterior two-thirds corpus callosotomy may be valuable in reducing seizure frequency in some children, it is currently not possible to predict accurately which children will benefit from the procedure.",
keywords = "Corpus callosum, Epilepsy",
author = "Makari, {George S.} and Holmes, {Gregory L.} and Murro, {Anthony M} and Smith, {Joseph R.} and Flanigin, {Herman F.} and Cohen, {Morris J.} and Kyoon Huh and Gallagher, {Brian S.} and Ackell, {Adele B.} and Rebecca Campbell and King, {Don W.}",
year = "1989",
doi = "10.1016/0896-6974(89)90052-2",
language = "English (US)",
volume = "2",
pages = "1--7",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Corpus callosotomy for the treatment of intractable epilepsy in children

AU - Makari, George S.

AU - Holmes, Gregory L.

AU - Murro, Anthony M

AU - Smith, Joseph R.

AU - Flanigin, Herman F.

AU - Cohen, Morris J.

AU - Huh, Kyoon

AU - Gallagher, Brian S.

AU - Ackell, Adele B.

AU - Campbell, Rebecca

AU - King, Don W.

PY - 1989

Y1 - 1989

N2 - We report the results of anterior two-thirds corpus callosotomies in 20 children undergoing the procedure for intractable seizures. All children recovered from the callosotomy without significant neurological sequelae. Excellent results with regard to seizure frequency were found in 8 of 20 (40%) patients. Following surgery, generalized tonic-clonic seizures, tonic seizures, and atonic seizures were reduced from their preoperative frequency. Although all patients in the postoperative period continued on antiepileptic drugs, there was a significant reduction in the number of drugs used. There was no statistically significant relationship between outcome and age of onset of the seizures, presence or absence of mental retardation, computerized tomography or magnetic resonance imaging findings, presence of hemiplegia, and preoperative EEG abnormalities. Although anterior two-thirds corpus callosotomy may be valuable in reducing seizure frequency in some children, it is currently not possible to predict accurately which children will benefit from the procedure.

AB - We report the results of anterior two-thirds corpus callosotomies in 20 children undergoing the procedure for intractable seizures. All children recovered from the callosotomy without significant neurological sequelae. Excellent results with regard to seizure frequency were found in 8 of 20 (40%) patients. Following surgery, generalized tonic-clonic seizures, tonic seizures, and atonic seizures were reduced from their preoperative frequency. Although all patients in the postoperative period continued on antiepileptic drugs, there was a significant reduction in the number of drugs used. There was no statistically significant relationship between outcome and age of onset of the seizures, presence or absence of mental retardation, computerized tomography or magnetic resonance imaging findings, presence of hemiplegia, and preoperative EEG abnormalities. Although anterior two-thirds corpus callosotomy may be valuable in reducing seizure frequency in some children, it is currently not possible to predict accurately which children will benefit from the procedure.

KW - Corpus callosum

KW - Epilepsy

UR - http://www.scopus.com/inward/record.url?scp=0024956669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024956669&partnerID=8YFLogxK

U2 - 10.1016/0896-6974(89)90052-2

DO - 10.1016/0896-6974(89)90052-2

M3 - Article

AN - SCOPUS:0024956669

VL - 2

SP - 1

EP - 7

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 1

ER -