Correlates of femoral artery flow mediated dilation in a multi-ethnic sample of 12- to 26-year-olds

Bryan Hartley, Frank A. Treiber, David Ludwig, Kakota Gaston Kapuku

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: Endothelial dysfunction is one of the earliest events in the pathogenesis of cardiovascular disease (CVD). Studies involving healthy adults have found endothelial function, measured via flow mediated dilation (FMD), to be impaired in African Americans (AAs) compared to European Americans (EAs). The purpose of this study was to determine whether ethnic differences exist in FMD in a group of healthy teenagers and young adults, and to examine separately, by ethnic group, the relationships between FMD and several measures of adverse cardiovascular prognoses. Design: Subjects underwent measurement of various anthropometric, hemodynamic, and echocardiographic variables. Setting: Measurements were made in a laboratory setting. Participants: Subjects were 159 12- to 26-year-old AAs and EAs. Main Outcome Measures: FMD, endothelin-1 (ET-1) levels, at rest and in response to stress, and measures of cardiac structure and function. Results: Ethnic differences were not observed in FMD. Only pre-occlusion arterial diameter was significantly related to FMD in EAs (P<.001); whereas, among AAs, FMD was negatively correlated (all Ps<.03) with gender, pre-occlusion arterial diameter, relative wall thickness (RWT), resting plasma ET-1, and ET-1 increases, related to a behavioral stressor. Multiple linear regressions for AAs revealed that gender and RWT each explained a unique variation in FMD (Total model R2 = .36, P<.0001). Conclusion: Ethnic differences in FMD are not in evidence for subjects in this age range. The inverse relationships observed in AAs between FMD and measures of altered endothelial system function, and ventricular structure and function, provide additional evidence for early clustering of measures of adverse cardiovascular prognoses in this group.

Original languageEnglish (US)
Pages (from-to)227-232
Number of pages6
JournalEthnicity and Disease
Volume14
Issue number2
StatePublished - Mar 1 2004

Fingerprint

Femoral Artery
Dilatation
African Americans
Endothelin-1
Ventricular Function
Ethnic Groups
Cluster Analysis
Young Adult
Linear Models
Cardiovascular Diseases
Hemodynamics
Outcome Assessment (Health Care)

Keywords

  • Endothelial function
  • Endothelin-1
  • Ethnicity
  • Flow mediated dilation
  • Youth

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Medicine(all)

Cite this

Correlates of femoral artery flow mediated dilation in a multi-ethnic sample of 12- to 26-year-olds. / Hartley, Bryan; Treiber, Frank A.; Ludwig, David; Kapuku, Kakota Gaston.

In: Ethnicity and Disease, Vol. 14, No. 2, 01.03.2004, p. 227-232.

Research output: Contribution to journalArticle

Hartley, Bryan ; Treiber, Frank A. ; Ludwig, David ; Kapuku, Kakota Gaston. / Correlates of femoral artery flow mediated dilation in a multi-ethnic sample of 12- to 26-year-olds. In: Ethnicity and Disease. 2004 ; Vol. 14, No. 2. pp. 227-232.
@article{d1f52a603b5344b498707136ff77ac7b,
title = "Correlates of femoral artery flow mediated dilation in a multi-ethnic sample of 12- to 26-year-olds",
abstract = "Objective: Endothelial dysfunction is one of the earliest events in the pathogenesis of cardiovascular disease (CVD). Studies involving healthy adults have found endothelial function, measured via flow mediated dilation (FMD), to be impaired in African Americans (AAs) compared to European Americans (EAs). The purpose of this study was to determine whether ethnic differences exist in FMD in a group of healthy teenagers and young adults, and to examine separately, by ethnic group, the relationships between FMD and several measures of adverse cardiovascular prognoses. Design: Subjects underwent measurement of various anthropometric, hemodynamic, and echocardiographic variables. Setting: Measurements were made in a laboratory setting. Participants: Subjects were 159 12- to 26-year-old AAs and EAs. Main Outcome Measures: FMD, endothelin-1 (ET-1) levels, at rest and in response to stress, and measures of cardiac structure and function. Results: Ethnic differences were not observed in FMD. Only pre-occlusion arterial diameter was significantly related to FMD in EAs (P<.001); whereas, among AAs, FMD was negatively correlated (all Ps<.03) with gender, pre-occlusion arterial diameter, relative wall thickness (RWT), resting plasma ET-1, and ET-1 increases, related to a behavioral stressor. Multiple linear regressions for AAs revealed that gender and RWT each explained a unique variation in FMD (Total model R2 = .36, P<.0001). Conclusion: Ethnic differences in FMD are not in evidence for subjects in this age range. The inverse relationships observed in AAs between FMD and measures of altered endothelial system function, and ventricular structure and function, provide additional evidence for early clustering of measures of adverse cardiovascular prognoses in this group.",
keywords = "Endothelial function, Endothelin-1, Ethnicity, Flow mediated dilation, Youth",
author = "Bryan Hartley and Treiber, {Frank A.} and David Ludwig and Kapuku, {Kakota Gaston}",
year = "2004",
month = "3",
day = "1",
language = "English (US)",
volume = "14",
pages = "227--232",
journal = "Ethnicity and Disease",
issn = "1049-510X",
publisher = "ISHIB",
number = "2",

}

TY - JOUR

T1 - Correlates of femoral artery flow mediated dilation in a multi-ethnic sample of 12- to 26-year-olds

AU - Hartley, Bryan

AU - Treiber, Frank A.

AU - Ludwig, David

AU - Kapuku, Kakota Gaston

PY - 2004/3/1

Y1 - 2004/3/1

N2 - Objective: Endothelial dysfunction is one of the earliest events in the pathogenesis of cardiovascular disease (CVD). Studies involving healthy adults have found endothelial function, measured via flow mediated dilation (FMD), to be impaired in African Americans (AAs) compared to European Americans (EAs). The purpose of this study was to determine whether ethnic differences exist in FMD in a group of healthy teenagers and young adults, and to examine separately, by ethnic group, the relationships between FMD and several measures of adverse cardiovascular prognoses. Design: Subjects underwent measurement of various anthropometric, hemodynamic, and echocardiographic variables. Setting: Measurements were made in a laboratory setting. Participants: Subjects were 159 12- to 26-year-old AAs and EAs. Main Outcome Measures: FMD, endothelin-1 (ET-1) levels, at rest and in response to stress, and measures of cardiac structure and function. Results: Ethnic differences were not observed in FMD. Only pre-occlusion arterial diameter was significantly related to FMD in EAs (P<.001); whereas, among AAs, FMD was negatively correlated (all Ps<.03) with gender, pre-occlusion arterial diameter, relative wall thickness (RWT), resting plasma ET-1, and ET-1 increases, related to a behavioral stressor. Multiple linear regressions for AAs revealed that gender and RWT each explained a unique variation in FMD (Total model R2 = .36, P<.0001). Conclusion: Ethnic differences in FMD are not in evidence for subjects in this age range. The inverse relationships observed in AAs between FMD and measures of altered endothelial system function, and ventricular structure and function, provide additional evidence for early clustering of measures of adverse cardiovascular prognoses in this group.

AB - Objective: Endothelial dysfunction is one of the earliest events in the pathogenesis of cardiovascular disease (CVD). Studies involving healthy adults have found endothelial function, measured via flow mediated dilation (FMD), to be impaired in African Americans (AAs) compared to European Americans (EAs). The purpose of this study was to determine whether ethnic differences exist in FMD in a group of healthy teenagers and young adults, and to examine separately, by ethnic group, the relationships between FMD and several measures of adverse cardiovascular prognoses. Design: Subjects underwent measurement of various anthropometric, hemodynamic, and echocardiographic variables. Setting: Measurements were made in a laboratory setting. Participants: Subjects were 159 12- to 26-year-old AAs and EAs. Main Outcome Measures: FMD, endothelin-1 (ET-1) levels, at rest and in response to stress, and measures of cardiac structure and function. Results: Ethnic differences were not observed in FMD. Only pre-occlusion arterial diameter was significantly related to FMD in EAs (P<.001); whereas, among AAs, FMD was negatively correlated (all Ps<.03) with gender, pre-occlusion arterial diameter, relative wall thickness (RWT), resting plasma ET-1, and ET-1 increases, related to a behavioral stressor. Multiple linear regressions for AAs revealed that gender and RWT each explained a unique variation in FMD (Total model R2 = .36, P<.0001). Conclusion: Ethnic differences in FMD are not in evidence for subjects in this age range. The inverse relationships observed in AAs between FMD and measures of altered endothelial system function, and ventricular structure and function, provide additional evidence for early clustering of measures of adverse cardiovascular prognoses in this group.

KW - Endothelial function

KW - Endothelin-1

KW - Ethnicity

KW - Flow mediated dilation

KW - Youth

UR - http://www.scopus.com/inward/record.url?scp=3242752128&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242752128&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 227

EP - 232

JO - Ethnicity and Disease

JF - Ethnicity and Disease

SN - 1049-510X

IS - 2

ER -