Correlation between serum and urinary calcium levels and psychopathology in patients with affective disorders: Short Communication

J. E. Stern, S. M. Guinjoan, D. P. Cardinali

Research output: Contribution to journalArticle

2 Scopus citations


To examine whether serum and urinary calcium levels were related to the psychopathology index (i.e. average score in clinically relevant scales of Minnesota Multiphasic Personality Inventory), 24 women aged 35.6 ± 2.5 years and 20 men aged 34.3 ± 2.1 years, suffering from affective disorders, were studied. A non-parametric bivariate correlation analysis revealed a negative correlation between PI and serum calcium (r = -0.256, p < 0.01), while urinary calcium levels correlated positively with PI (r = 0.236, p < 0.02). A positive correlation occurred between serum and urinary calcium (r = 0.968, p < 0.0001). When the data were analyzed by categorical classification of patients with normal or abnormal PI scores, serum calcium levels were smaller, and urinary calcium levels higher, in patients with abnormal PI (p < 0.01). The results support to the concept that alterations of calcium homeostasis occur in psychopathology.

Original languageEnglish (US)
Pages (from-to)509-513
Number of pages5
JournalJournal of Neural Transmission
Issue number4
Publication statusPublished - Jan 1 1996



  • Autonomic nervous system
  • Calcium metabolism
  • MMPI
  • Psychopathology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

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