Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters

Mark O. Goodarzi, Xiuqing Guo, Bulent O. Yildiz, Frank Z. Stanczyk, Ricardo Azziz

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: The purpose of this study was to assess the sibling correlation of adrenocorticotropic hormone-stimulated steroid hormone levels between probands with polycystic ovary syndrome and their sisters. Study Design: Twenty-seven women with polycystic ovary syndrome and 28 of their sisters underwent an adrenocorticotropic hormone stimulation test with measurement of the steroids dehydroepiandrosterone, androstenedione, and cortisol 60 minutes later. The 60-minute values were used to calculate sister-sister correlations by regression analyses. Results: The adrenocorticotropic hormone-stimulated (60-minute) log-transformed dehydroepiandrosterone and cortisol values were significantly correlated between siblings (r = 0.47, P = .01 and r = 0.57, P = .01, respectively); a similar trend was observed for the 60-minute A4 values (r = 0.29, P = .06). Conclusion: Women with polycystic ovary syndrome and their sisters have significantly correlated levels of adrenocorticotropic hormone-stimulated steroids, supporting a genetic basis of the adrenal androgen excess observed in polycystic ovary syndrome.

Original languageEnglish (US)
Pages (from-to)398.e1-398.e6
JournalAmerican Journal of Obstetrics and Gynecology
Volume196
Issue number4
DOIs
StatePublished - Jan 1 2007

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Polycystic Ovary Syndrome
Adrenocorticotropic Hormone
Siblings
Steroids
Dehydroepiandrosterone
Hydrocortisone
Androstenedione
Androgens
Regression Analysis
Hormones

Keywords

  • adrenal
  • androgen excess
  • genetics
  • polycystic ovary syndrome
  • sibling correlation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters. / Goodarzi, Mark O.; Guo, Xiuqing; Yildiz, Bulent O.; Stanczyk, Frank Z.; Azziz, Ricardo.

In: American Journal of Obstetrics and Gynecology, Vol. 196, No. 4, 01.01.2007, p. 398.e1-398.e6.

Research output: Contribution to journalArticle

Goodarzi, Mark O. ; Guo, Xiuqing ; Yildiz, Bulent O. ; Stanczyk, Frank Z. ; Azziz, Ricardo. / Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters. In: American Journal of Obstetrics and Gynecology. 2007 ; Vol. 196, No. 4. pp. 398.e1-398.e6.
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