Correlation of normal diastolic cardiac function with VO2max in the metabolic syndrome

Anand Chockalingam, Melissa A. Linden, Kevin C. Dellsperger, Tom R. Thomas

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Morbid obesity and diabetes cause diastolic dysfunction that can be detected by Doppler echocardiography. Patients with the metabolic syndrome could demonstrate early diastolic dysfunction that may influence effort tolerance. A total of 32 patients (17 men) who fulfilled ≥2 of the 5 metabolic syndrome criteria were studied. The average age of patients was 37 ± 2 years. All patients were overweight/obese (mean body mass index of 34.4 ± 0.7kg/m2), 15 had blood pressure >130/85mm Hg, 19 had elevated triglyceride levels (>150 mg/dL), and 17 had low high-density lipoprotein cholesterol levels (men < 40 mg/dL, women <50 mg/dL). Maximal exercise was performed using Bruce treadmill protocol with standard stress echocardiography and tissue Doppler. Maximal oxygen consumption (VO2max) was measured using indirect calorimetry. Left ventricular filling pressure was indirectly derived from dividing pulse Doppler early mitral inflow velocity (E) by tissue Doppler early diastolic mitral annular motion (E′) or E/E′. The group's average treadmill time was 8.06 ± 0.28 minutes, VO2max was 28.6 ± 1.1mL/kg/min, and 8.2 ± 0.3 metabolic equivalents. None had evidence of myocardial ischemia or systolic or diastolic dysfunction with exercise. Mean "resting" E/E′ and "post-exercise" E/E′ were 7.01±0.04 and 7.41±0.41, respectively. There was no significant correlation between resting E/E ′ and VO2max (r = -0.266; P = .14). The post-exercise E/E′ significantly correlated with VO2max (r = -0.483; P = .005) and metabolic equivalents (r = -0.487; P = .005). Diastolic function is preserved in early metabolic syndrome. Even in the normal diastolic function range, exercise E/E′ is inversely related to VO2max. Further longitudinal studies are needed to determine whether they develop diastolic dysfunction and related heart failure.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalPreventive cardiology
Issue number3
StatePublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Cardiology and Cardiovascular Medicine


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