Cortical gene transcription response patterns to water maze training in aged mice

Sung Soo Park, Alexis M. Stranahan, Wayne Chadwick, Yu Zhou, Liyun Wang, Bronwen Martin, Kevin G. Becker, Stuart Maudsley

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background: The hippocampus mediates the acquisition of spatial memory, but the memory trace is eventually transferred to the cortex. We have investigated transcriptional activation of pathways related to cognitive function in the cortex of the aged mouse by analyzing gene expression following water maze training.Results: We identified genes that were differentially responsive in aged mice with accurate spatial performance during probe trials or repeated swimming sessions, relative to home cage conditions. Effective learners exhibited significantly greater activation of several pathways, such as the mitogen-activated protein kinase and insulin receptor signaling pathways, relative to swimmers. The genes encoding activity-related cytoskeletal protein (Arc) and brain-derived neurotrophic factor (BDNF) were upregulated in proficient learners, relative to swimmers and home cage controls, while the gene encoding Rho GTPase activating protein 32 (GRIT) was downregulated. We explored the regulation of Arc, BDNF, and GRIT expression in greater morphological detail using in situ hybridization. Recall during probe trials enhanced Arc expression across multiple cortical regions involved in the cognitive component of water maze learning, while BDNF expression was more homogeneously upregulated across cortical regions involved in the associational and sensorimotor aspects of water maze training. In contrast, levels of GRIT expression were uniformly reduced across all cortical regions examined.Conclusions: These results suggest that cortical gene transcription is responsive to learning in aged mice that exhibit behavioral proficiency, and support a distributed hypothesis of memory storage across multiple cortical compartments.

Original languageEnglish (US)
Article number63
JournalBMC Neuroscience
Volume12
DOIs
StatePublished - Jun 29 2011

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

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    Park, S. S., Stranahan, A. M., Chadwick, W., Zhou, Y., Wang, L., Martin, B., Becker, K. G., & Maudsley, S. (2011). Cortical gene transcription response patterns to water maze training in aged mice. BMC Neuroscience, 12, [63]. https://doi.org/10.1186/1471-2202-12-63