Cortical localization of human sustained attention

Detection with functional MR using a visual vigilance paradigm

Jonathan S. Lewin, Lee Friedman, Dee Wu, David A. Miller, Lee A. Thompson, Susan K. Klein, Alexandria L. Wise, Peter Hedera, Peter F Buckley, Herbert Meltzer, Robert P. Friedland, Jeffrey L. Duerk

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Purpose: Our goal was to determine whether functional MRI on a standard 1.5 T system can localize activation during a visual vigilance sustained attention task and whether this corresponds to results described in a PET investigation of a similar task. Method: Sixteen volunteers were studied on a 1.5 T system using a gradient echo technique. A single axial section was oriented within a stereotaxic coordinate space, 40 mm superior to the anterior-posterior commissure line. Images with eyes closed were followed by images during subject concentration on a small dim spot. Motion correction and pixel-by-pixel statistical analysis were performed. Talairach grids were applied for summary statistical analysis and comparison to PET data, with analysis using a series of planned contrasts within a repeated measures analysis of variance. Results: Predominantly right-sided frontal and parietal activation was observed, with statistical significance across subjects in the right frontal lobe (F ≤ 5.9, p ≤ 0.041). Comparison with previously reported PET data yielded a very similar pattern of activation (F = 13.2; df = 1.8; p = 0.007). Conclusion: Activation of the right middle frontal gyrus and right parietal lobe during visual vigilance is detectable across functional imaging modalities.

Original languageEnglish (US)
Pages (from-to)695-701
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume20
Issue number5
DOIs
StatePublished - Sep 1 1996

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Parietal Lobe
Frontal Lobe
Volunteers
Analysis of Variance
Magnetic Resonance Imaging

Keywords

  • Blood, flow dynamics
  • Brain
  • Brain, blood flow
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Cortical localization of human sustained attention : Detection with functional MR using a visual vigilance paradigm. / Lewin, Jonathan S.; Friedman, Lee; Wu, Dee; Miller, David A.; Thompson, Lee A.; Klein, Susan K.; Wise, Alexandria L.; Hedera, Peter; Buckley, Peter F; Meltzer, Herbert; Friedland, Robert P.; Duerk, Jeffrey L.

In: Journal of Computer Assisted Tomography, Vol. 20, No. 5, 01.09.1996, p. 695-701.

Research output: Contribution to journalArticle

Lewin, JS, Friedman, L, Wu, D, Miller, DA, Thompson, LA, Klein, SK, Wise, AL, Hedera, P, Buckley, PF, Meltzer, H, Friedland, RP & Duerk, JL 1996, 'Cortical localization of human sustained attention: Detection with functional MR using a visual vigilance paradigm', Journal of Computer Assisted Tomography, vol. 20, no. 5, pp. 695-701. https://doi.org/10.1097/00004728-199609000-00002
Lewin, Jonathan S. ; Friedman, Lee ; Wu, Dee ; Miller, David A. ; Thompson, Lee A. ; Klein, Susan K. ; Wise, Alexandria L. ; Hedera, Peter ; Buckley, Peter F ; Meltzer, Herbert ; Friedland, Robert P. ; Duerk, Jeffrey L. / Cortical localization of human sustained attention : Detection with functional MR using a visual vigilance paradigm. In: Journal of Computer Assisted Tomography. 1996 ; Vol. 20, No. 5. pp. 695-701.
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