TY - JOUR
T1 - Cortical visual impairment in congenital cytomegalovirus infection
AU - The Congenital CMV Longitudinal Group
AU - Jin, Haoxing Douglas
AU - Demmler-Harrison, Gail J.
AU - Miller, Jerry
AU - Edmond, Jane C.
AU - Coats, David K.
AU - Paysse, Evelyn A.
AU - Bhatt, Amit R.
AU - Yen, Kimberly G.
AU - Klingen, Joseph T.
AU - Steinkuller, Paul
N1 - Funding Information:
Supported in part by the CMV Research Fund Donors at Baylor College of Medicine; the Woman's Hospital of Texas Research Foundation; the Office of Research Resources and the General Clinical Research Center for Children at Texas Children's Hospital and Baylor College of Medicine (NIH 5M0I RR00188-33); the Mental Retardation Research Center at Baylor College of Medicine (NIH-CHHD 5 P30 HD24064P); Research to Prevent Blindness, Inc., New York, NY; the Deafness Foundation, Houston, TX; the Vale Ashe Foundation, Houston, TX; the Maddie's Mission Foundation, Katy, TX; the Naymola Charitable Foundation, Beaumont, TX; the American Pediatric Society-Society for Pediatric Research Summer Student Research Program (NIH-CHHD); and Merck & Co. and the Centers for Disease Control and Prevention (Cooperative Agreement FOA IP 10-006).
PY - 2019
Y1 - 2019
N2 - Purpose: To describe the presentation, evolution, and long-term outcome of cortical visual impairment (CVI) in patients with symptomatic congenital cytomegalovirus (CMV) infection, and to identify risk factors for the development of CVI in patients with symptomatic congenital CMV. Methods: Retrospective subanalysis of a long-term prospective cohort study with data gathered from 1982 to 2013. Results: Eleven of 77 (14.3%) patients with symptomatic CMV, 0 of 109 with asymptomatic CMV, and 51 control patients had CVI. Overall, patients with symptomatic CMV had worse vision than patients with asymptomatic CMV, who in turn had worse vision than control patients. Microcephaly, intracranial calcification, dilatation of ventricles, encephalomalacia, seizure at birth, optic atrophy, chorioretinitis/retinal scars, strabismus, and neonatal onset of sensorineural hearing loss were risk factors associated with CVI. Conclusions: CVI may result from symptomatic congenital CMV infection. The relationship of CVI and its risk factors in patients with CMV suggests the potential to predict the development of CVI through predictive modeling in future research. Early screening of CVI in children born with symptomatic congenital CMV can facilitate educational, social, and developmental interventions.
AB - Purpose: To describe the presentation, evolution, and long-term outcome of cortical visual impairment (CVI) in patients with symptomatic congenital cytomegalovirus (CMV) infection, and to identify risk factors for the development of CVI in patients with symptomatic congenital CMV. Methods: Retrospective subanalysis of a long-term prospective cohort study with data gathered from 1982 to 2013. Results: Eleven of 77 (14.3%) patients with symptomatic CMV, 0 of 109 with asymptomatic CMV, and 51 control patients had CVI. Overall, patients with symptomatic CMV had worse vision than patients with asymptomatic CMV, who in turn had worse vision than control patients. Microcephaly, intracranial calcification, dilatation of ventricles, encephalomalacia, seizure at birth, optic atrophy, chorioretinitis/retinal scars, strabismus, and neonatal onset of sensorineural hearing loss were risk factors associated with CVI. Conclusions: CVI may result from symptomatic congenital CMV infection. The relationship of CVI and its risk factors in patients with CMV suggests the potential to predict the development of CVI through predictive modeling in future research. Early screening of CVI in children born with symptomatic congenital CMV can facilitate educational, social, and developmental interventions.
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U2 - 10.3928/01913913-20190311-01
DO - 10.3928/01913913-20190311-01
M3 - Article
C2 - 31116869
AN - SCOPUS:85066466683
VL - 56
SP - 194
EP - 202
JO - Journal of Pediatric Ophthalmology and Strabismus
JF - Journal of Pediatric Ophthalmology and Strabismus
SN - 0191-3913
IS - 3
ER -