Corticospinal axons persist in cervical and high thoracic regions 10 weeks after a T-9 spinal cord transection

Jerry N Pruitt, Earl R. Feringa, Russell L. McBride

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Abstract

Ten weeks after complete spinal cord transection at T-9, there was a decrease in the volume of the rat corticospinal tract but no loss in the number of axon8 contained in the cervical (C-2) or high thoracic (T-1) corticospinal tract. The mean area of the myelinated axon profile decreased in spinal cord-transected rats, with fewer axons found in the largest size groups and more in the smaller size groups. The survival of corticospinal axons in the cervical and thoracic cord 10 weeks after cord transection at T-9 indicates that the corticospinal neurons survive at least 10 weeks after cord transection. The fate of axotomized neurons after longer survival times remains to be determined.

Original languageEnglish (US)
Pages (from-to)946-950
Number of pages5
JournalNeurology
Volume38
Issue number6
Publication statusPublished - Jun 1988

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ASJC Scopus subject areas

  • Clinical Neurology

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