Craniofacial morphology in myostatin-deficient mice

L. Vecchione, C. Byron, G. M. Cooper, T. Barbano, Mark W Hamrick, J. J. Sciote, M. P. Mooney

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

GDF-8 (myostatin) is a negative growth regulator of skeletal muscle, and myostatin-deficient mice are hypermuscular. Muscle size and force production are thought to influence growth of the craniofacial skeleton. To test this relationship, we compared masticatory muscle size and craniofacial dimensions in myostatin-deficient and wild-type CD-1 control mice. Myostatin-deficient mice had significantly (p < 0.01) greater body (by 18%) and masseter muscle weight (by 83%), compared with wild-type controls. Significant differences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length, and mandibular shape index. Significant correlations were noted between masseter muscle weight and mandibular body length (r = 0.68; p < 0.01), cranial vault length (r = -0.57; p < 0.05), and the mandibular shape index (r = -0.56; p < 0.05). Masticatory hypermuscularity resulted in significantly altered craniofacial morphology, probably through altered biomechanical stress. These findings emphasize the important role that masticatory muscle function plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.

Original languageEnglish (US)
Pages (from-to)1068-1072
Number of pages5
JournalJournal of Dental Research
Volume86
Issue number11
DOIs
StatePublished - Nov 1 2007

Fingerprint

Myostatin
Masticatory Muscles
Masseter Muscle
Maxilla
Growth
Mandible
Skeleton
Skeletal Muscle
Body Weight
Weights and Measures
Muscles

Keywords

  • Craniofacial growth
  • Mice
  • Morphology
  • Myostatin

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Vecchione, L., Byron, C., Cooper, G. M., Barbano, T., Hamrick, M. W., Sciote, J. J., & Mooney, M. P. (2007). Craniofacial morphology in myostatin-deficient mice. Journal of Dental Research, 86(11), 1068-1072. https://doi.org/10.1177/154405910708601109

Craniofacial morphology in myostatin-deficient mice. / Vecchione, L.; Byron, C.; Cooper, G. M.; Barbano, T.; Hamrick, Mark W; Sciote, J. J.; Mooney, M. P.

In: Journal of Dental Research, Vol. 86, No. 11, 01.11.2007, p. 1068-1072.

Research output: Contribution to journalArticle

Vecchione, L, Byron, C, Cooper, GM, Barbano, T, Hamrick, MW, Sciote, JJ & Mooney, MP 2007, 'Craniofacial morphology in myostatin-deficient mice', Journal of Dental Research, vol. 86, no. 11, pp. 1068-1072. https://doi.org/10.1177/154405910708601109
Vecchione L, Byron C, Cooper GM, Barbano T, Hamrick MW, Sciote JJ et al. Craniofacial morphology in myostatin-deficient mice. Journal of Dental Research. 2007 Nov 1;86(11):1068-1072. https://doi.org/10.1177/154405910708601109
Vecchione, L. ; Byron, C. ; Cooper, G. M. ; Barbano, T. ; Hamrick, Mark W ; Sciote, J. J. ; Mooney, M. P. / Craniofacial morphology in myostatin-deficient mice. In: Journal of Dental Research. 2007 ; Vol. 86, No. 11. pp. 1068-1072.
@article{930ba6dddea74d3a8986500f614c2446,
title = "Craniofacial morphology in myostatin-deficient mice",
abstract = "GDF-8 (myostatin) is a negative growth regulator of skeletal muscle, and myostatin-deficient mice are hypermuscular. Muscle size and force production are thought to influence growth of the craniofacial skeleton. To test this relationship, we compared masticatory muscle size and craniofacial dimensions in myostatin-deficient and wild-type CD-1 control mice. Myostatin-deficient mice had significantly (p < 0.01) greater body (by 18{\%}) and masseter muscle weight (by 83{\%}), compared with wild-type controls. Significant differences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length, and mandibular shape index. Significant correlations were noted between masseter muscle weight and mandibular body length (r = 0.68; p < 0.01), cranial vault length (r = -0.57; p < 0.05), and the mandibular shape index (r = -0.56; p < 0.05). Masticatory hypermuscularity resulted in significantly altered craniofacial morphology, probably through altered biomechanical stress. These findings emphasize the important role that masticatory muscle function plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.",
keywords = "Craniofacial growth, Mice, Morphology, Myostatin",
author = "L. Vecchione and C. Byron and Cooper, {G. M.} and T. Barbano and Hamrick, {Mark W} and Sciote, {J. J.} and Mooney, {M. P.}",
year = "2007",
month = "11",
day = "1",
doi = "10.1177/154405910708601109",
language = "English (US)",
volume = "86",
pages = "1068--1072",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",
number = "11",

}

TY - JOUR

T1 - Craniofacial morphology in myostatin-deficient mice

AU - Vecchione, L.

AU - Byron, C.

AU - Cooper, G. M.

AU - Barbano, T.

AU - Hamrick, Mark W

AU - Sciote, J. J.

AU - Mooney, M. P.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - GDF-8 (myostatin) is a negative growth regulator of skeletal muscle, and myostatin-deficient mice are hypermuscular. Muscle size and force production are thought to influence growth of the craniofacial skeleton. To test this relationship, we compared masticatory muscle size and craniofacial dimensions in myostatin-deficient and wild-type CD-1 control mice. Myostatin-deficient mice had significantly (p < 0.01) greater body (by 18%) and masseter muscle weight (by 83%), compared with wild-type controls. Significant differences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length, and mandibular shape index. Significant correlations were noted between masseter muscle weight and mandibular body length (r = 0.68; p < 0.01), cranial vault length (r = -0.57; p < 0.05), and the mandibular shape index (r = -0.56; p < 0.05). Masticatory hypermuscularity resulted in significantly altered craniofacial morphology, probably through altered biomechanical stress. These findings emphasize the important role that masticatory muscle function plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.

AB - GDF-8 (myostatin) is a negative growth regulator of skeletal muscle, and myostatin-deficient mice are hypermuscular. Muscle size and force production are thought to influence growth of the craniofacial skeleton. To test this relationship, we compared masticatory muscle size and craniofacial dimensions in myostatin-deficient and wild-type CD-1 control mice. Myostatin-deficient mice had significantly (p < 0.01) greater body (by 18%) and masseter muscle weight (by 83%), compared with wild-type controls. Significant differences (p < 0.05) were noted for cranial vault length, maxillary length, mandibular body length, and mandibular shape index. Significant correlations were noted between masseter muscle weight and mandibular body length (r = 0.68; p < 0.01), cranial vault length (r = -0.57; p < 0.05), and the mandibular shape index (r = -0.56; p < 0.05). Masticatory hypermuscularity resulted in significantly altered craniofacial morphology, probably through altered biomechanical stress. These findings emphasize the important role that masticatory muscle function plays in the ontogeny of the cranial vault, the maxilla, and, most notably, the mandible.

KW - Craniofacial growth

KW - Mice

KW - Morphology

KW - Myostatin

UR - http://www.scopus.com/inward/record.url?scp=36549025066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36549025066&partnerID=8YFLogxK

U2 - 10.1177/154405910708601109

DO - 10.1177/154405910708601109

M3 - Article

C2 - 17959898

AN - SCOPUS:36549025066

VL - 86

SP - 1068

EP - 1072

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 11

ER -