'Cross-talk' between Schwannian stroma and neuroblasts promotes neuroblastoma tumor differentiation and inhibits angiogenesis

Shuqing Liu, Yufeng Tian, Alexandre Chlenski, Qiwei Yang, Helen R. Salwen, Susan L. Cohn

Research output: Contribution to journalShort survey

18 Scopus citations

Abstract

Neuroblastoma (NB) tumors with abundant Schwannian stroma have a differentiated phenotype, low vascularity, and are associated with a favorable prognosis. These observations have led to the hypothesis that 'cross-talk' between Schwann cells and neuroblasts influences the biology and clinical behavior of NB tumors. In support of this hypothesis, laboratory studies have shown that factors secreted by Schwann cells are capable of promoting NB differentiation, inhibiting angiogenesis, and impairing NB growth. Recently, using a novel NB xenograft model that was designed to directly investigate the affects of infiltrating Schwann cells, we demonstrated that infiltrating mouse Schwann cells can directly impact the phenotype of human NB xenografts in vivo. Taken together, these studies indicate that tumor-stroma interactions are critical in determining the biology of NB tumors. Further research investigating the molecules involved in the 'cross-talk' between Schwann cells and neuroblasts may lead to new treatment strategies that will modify tumor biology and alter the clinically aggressive nature of Schwannian stroma-poor NB tumors.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalCancer Letters
Volume228
Issue number1-2
DOIs
StatePublished - Oct 18 2005

Keywords

  • Angiogenesis
  • Apoptosis
  • Differentiation
  • Neuroblastoma
  • Schwann cell

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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