Cross talk between the notch signaling and noncoding RNA on the fate of stem cells

Yaoliang Tang, Yingjie Wang, Lijuan Chen, Neal Weintraub, Yaohua Pan

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

The Notch signal pathway directly controls stem cell survival, proliferation, and differentiation. Noncoding RNAs, including small microRNAs (miRNAs) and long noncoding RNAs (LncRNAs), are responsible for fine regulation of gene expression. It is also becoming increasingly evident that miRNAs have a profound impact on the Notch signaling pathway; conversely, Notch signaling can regulate a handful of miRNAs that are involved in the stem cell function. In this chapter, we summarize our current knowledge of Notch-mediated stem cell differentiation and the cross talk between miRNAs and the Notch signal pathway on determining the fate of stem cells.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages175-193
Number of pages19
DOIs
StatePublished - 2012
Externally publishedYes

Publication series

NameProgress in Molecular Biology and Translational Science
Volume111
ISSN (Print)1877-1173

Keywords

  • LncRNA
  • MicroRNA network
  • Notch
  • Stem cells

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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