TY - JOUR
T1 - Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin
AU - Cottingham, Christopher
AU - Lu, Roujian
AU - Jiao, Kai
AU - Wang, Qin
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α2ARs accelerates α2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α2AAR endocytosis via PKA-dependent disruption of α2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.
AB - Background:Cross-talk between GPCRs is an important but undercharacterized mechanism regulating receptor responsiveness. Results:Co-activation of β and α2ARs accelerates α2AAR endocytosis in a PKA- and spinophilin-dependent fashion. Conclusion:βAR-mediated signaling modulates α2AAR endocytosis via PKA-dependent disruption of α2AAR/spinophilin interaction. Significance:Cross-talk from βto α2 ARs may have important implications in basal adrenergic tone and the pharmacology of commonly used adrenergic therapeutics.
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U2 - 10.1074/jbc.M113.469494
DO - 10.1074/jbc.M113.469494
M3 - Article
C2 - 23965992
AN - SCOPUS:84885143688
SN - 0021-9258
VL - 288
SP - 29193
EP - 29205
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 40
ER -