Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction

Arnab Barik, Bin Zhang, Gurkirpal S. Sohal, Wen Cheng Xiong, Lin Mei

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Neuromuscular junction (NMJ) is a cholinergic synapse where motor neurons elicit muscle contraction. Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation. This paper reviews recent evidence for Wnts and Wnt signaling molecules in NMJ formation including a possible retrograde mechanism by muscle β-catenin. We also present data that Wnt3a, 7a, 8a and 10b could inhibit agrin-mediated AChR clustering. Together with the stimulating effect of Wnt9a, 9b, 10b, 11 and 16 on AChR clustering in the absence of agrin, these results suggest diverse roles for Wnt ligands in NMJ development.

Original languageEnglish (US)
Pages (from-to)828-838
Number of pages11
JournalDevelopmental Neurobiology
Volume74
Issue number8
DOIs
StatePublished - Jan 1 2014

Fingerprint

Agrin
Wnt Signaling Pathway
Neuromuscular Junction
Vertebrates
Cluster Analysis
Catenins
Motor Neurons
Muscle Contraction
Synapses
Cholinergic Agents
Ligands
Muscles

Keywords

  • Aneural clusters
  • LRP4
  • Musk
  • NMJ
  • WNT

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. / Barik, Arnab; Zhang, Bin; Sohal, Gurkirpal S.; Xiong, Wen Cheng; Mei, Lin.

In: Developmental Neurobiology, Vol. 74, No. 8, 01.01.2014, p. 828-838.

Research output: Contribution to journalArticle

Barik, Arnab ; Zhang, Bin ; Sohal, Gurkirpal S. ; Xiong, Wen Cheng ; Mei, Lin. / Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. In: Developmental Neurobiology. 2014 ; Vol. 74, No. 8. pp. 828-838.
@article{515d61c2114740949e96c2705bc9241f,
title = "Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction",
abstract = "Neuromuscular junction (NMJ) is a cholinergic synapse where motor neurons elicit muscle contraction. Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation. This paper reviews recent evidence for Wnts and Wnt signaling molecules in NMJ formation including a possible retrograde mechanism by muscle β-catenin. We also present data that Wnt3a, 7a, 8a and 10b could inhibit agrin-mediated AChR clustering. Together with the stimulating effect of Wnt9a, 9b, 10b, 11 and 16 on AChR clustering in the absence of agrin, these results suggest diverse roles for Wnt ligands in NMJ development.",
keywords = "Aneural clusters, LRP4, Musk, NMJ, WNT",
author = "Arnab Barik and Bin Zhang and Sohal, {Gurkirpal S.} and Xiong, {Wen Cheng} and Lin Mei",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/dneu.22190",
language = "English (US)",
volume = "74",
pages = "828--838",
journal = "Developmental Neurobiology",
issn = "1932-8451",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

TY - JOUR

T1 - Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction

AU - Barik, Arnab

AU - Zhang, Bin

AU - Sohal, Gurkirpal S.

AU - Xiong, Wen Cheng

AU - Mei, Lin

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Neuromuscular junction (NMJ) is a cholinergic synapse where motor neurons elicit muscle contraction. Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation. This paper reviews recent evidence for Wnts and Wnt signaling molecules in NMJ formation including a possible retrograde mechanism by muscle β-catenin. We also present data that Wnt3a, 7a, 8a and 10b could inhibit agrin-mediated AChR clustering. Together with the stimulating effect of Wnt9a, 9b, 10b, 11 and 16 on AChR clustering in the absence of agrin, these results suggest diverse roles for Wnt ligands in NMJ development.

AB - Neuromuscular junction (NMJ) is a cholinergic synapse where motor neurons elicit muscle contraction. Agrin and its coreceptors LRP4 and MuSK are critical for vertebrate NMJ formation. This paper reviews recent evidence for Wnts and Wnt signaling molecules in NMJ formation including a possible retrograde mechanism by muscle β-catenin. We also present data that Wnt3a, 7a, 8a and 10b could inhibit agrin-mediated AChR clustering. Together with the stimulating effect of Wnt9a, 9b, 10b, 11 and 16 on AChR clustering in the absence of agrin, these results suggest diverse roles for Wnt ligands in NMJ development.

KW - Aneural clusters

KW - LRP4

KW - Musk

KW - NMJ

KW - WNT

UR - http://www.scopus.com/inward/record.url?scp=84903819812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903819812&partnerID=8YFLogxK

U2 - 10.1002/dneu.22190

DO - 10.1002/dneu.22190

M3 - Article

VL - 74

SP - 828

EP - 838

JO - Developmental Neurobiology

JF - Developmental Neurobiology

SN - 1932-8451

IS - 8

ER -