Crosstalk between perivascular adipose tissue and blood vessels

Srinivas Rajsheker, David Manka, Andra L. Blomkalns, Tapan K. Chatterjee, Lynn L. Stoll, Neal L. Weintraub

Research output: Contribution to journalReview article

109 Citations (Scopus)

Abstract

Crosstalk between cells in the blood vessel wall is vital to normal vascular function and is perturbed in diseases such as atherosclerosis and hypertension. Perivascular adipocytes reside at the adventitial border of blood vessels but until recently were virtually ignored in studies of vascular function. However, perivascular adipocytes have been demonstrated to be powerful endocrine cells capable of responding to metabolic cues and transducing signals to adjacent blood vessels. Accordingly, crosstalk between perivascular adipose tissue (PVAT) and blood vessels is now being intensely examined. Emerging evidence suggests that PVAT regulates vascular function through numerous mechanisms, but evidence to date suggests modulation of three key aspects that are the focus of this review: inflammation, vasoreactivity, and smooth muscle cell proliferation.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalCurrent Opinion in Pharmacology
Volume10
Issue number2
DOIs
StatePublished - Apr 1 2010

Fingerprint

Blood Vessels
Adipose Tissue
Adipocytes
Adventitia
Endocrine Cells
Smooth Muscle Myocytes
Cues
Atherosclerosis
Cell Proliferation
Hypertension
Inflammation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Rajsheker, S., Manka, D., Blomkalns, A. L., Chatterjee, T. K., Stoll, L. L., & Weintraub, N. L. (2010). Crosstalk between perivascular adipose tissue and blood vessels. Current Opinion in Pharmacology, 10(2), 191-196. https://doi.org/10.1016/j.coph.2009.11.005

Crosstalk between perivascular adipose tissue and blood vessels. / Rajsheker, Srinivas; Manka, David; Blomkalns, Andra L.; Chatterjee, Tapan K.; Stoll, Lynn L.; Weintraub, Neal L.

In: Current Opinion in Pharmacology, Vol. 10, No. 2, 01.04.2010, p. 191-196.

Research output: Contribution to journalReview article

Rajsheker, S, Manka, D, Blomkalns, AL, Chatterjee, TK, Stoll, LL & Weintraub, NL 2010, 'Crosstalk between perivascular adipose tissue and blood vessels', Current Opinion in Pharmacology, vol. 10, no. 2, pp. 191-196. https://doi.org/10.1016/j.coph.2009.11.005
Rajsheker, Srinivas ; Manka, David ; Blomkalns, Andra L. ; Chatterjee, Tapan K. ; Stoll, Lynn L. ; Weintraub, Neal L. / Crosstalk between perivascular adipose tissue and blood vessels. In: Current Opinion in Pharmacology. 2010 ; Vol. 10, No. 2. pp. 191-196.
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