Cryptococcal meningitis in pregnancy

Charles R. Stafford, John Fremont Fisher, Hossam E. Fadel, Ana V. Espinel-Ingroff, Smith Shadomy, Mary Hamby

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cryptococcal meningitis was diagnosed in a pregnant woman at 21 weeks' gestation. The availability of fetal tissues, blood, and amniotic fluid in such a patient receiving therapy with amphotericin B plus flucytosine afforded the opportunity to study the effects of the disease and therapeutic agents on the developing fetus. The amphotericin B concentration in amniotic fluid was 0.25 μg/ml and that of flucytosine was 168 μg/ml. The concentrations in cord blood were 0.3 μg/ml and 64.7 μg/ml, respectively. No evidence was found of amphotericin B or flucytosine toxicity in fetal tissues, although exposure of the fetus to these compounds was of brief duration.

Original languageEnglish (US)
Pages (from-to)35S-37S
JournalObstetrics and Gynecology
Volume62
Issue number3
StatePublished - Jan 1 1983

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Cryptococcal Meningitis
Flucytosine
Amphotericin B
Fetus
Pregnancy
Amniotic Fluid
Fetal Blood
Therapeutic Uses
Pregnant Women

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Stafford, C. R., Fisher, J. F., Fadel, H. E., Espinel-Ingroff, A. V., Shadomy, S., & Hamby, M. (1983). Cryptococcal meningitis in pregnancy. Obstetrics and Gynecology, 62(3), 35S-37S.

Cryptococcal meningitis in pregnancy. / Stafford, Charles R.; Fisher, John Fremont; Fadel, Hossam E.; Espinel-Ingroff, Ana V.; Shadomy, Smith; Hamby, Mary.

In: Obstetrics and Gynecology, Vol. 62, No. 3, 01.01.1983, p. 35S-37S.

Research output: Contribution to journalArticle

Stafford, CR, Fisher, JF, Fadel, HE, Espinel-Ingroff, AV, Shadomy, S & Hamby, M 1983, 'Cryptococcal meningitis in pregnancy', Obstetrics and Gynecology, vol. 62, no. 3, pp. 35S-37S.
Stafford CR, Fisher JF, Fadel HE, Espinel-Ingroff AV, Shadomy S, Hamby M. Cryptococcal meningitis in pregnancy. Obstetrics and Gynecology. 1983 Jan 1;62(3):35S-37S.
Stafford, Charles R. ; Fisher, John Fremont ; Fadel, Hossam E. ; Espinel-Ingroff, Ana V. ; Shadomy, Smith ; Hamby, Mary. / Cryptococcal meningitis in pregnancy. In: Obstetrics and Gynecology. 1983 ; Vol. 62, No. 3. pp. 35S-37S.
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