Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats

Farid A. Badria, Ahmed Salah Ibrahim, Adel F. Badria, Ahmed Abdelrazik Elmarakby

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objectives: Iron overload is now recognized as a health problem in industrialized countries, as excessive iron is highly toxic for liver and spleen. The potential use of curcumin as an iron chelator has not been clearly identified experimentally in iron overload condition. Here, we evaluate the efficacy of curcumin to alleviate iron overload-induced hepatic and splenic abnormalities and to gain insight into the underlying mechanisms. Design and Methods: Three groups of male adult rats were treated as follows: control rats, rats treated with iron in a drinking water for 2 months followed by either vehicle or curcumin treatment for 2 more months. Thereafter, we studied the effects of curcumin on iron overload-induced lipid peroxidation and anti-oxidant depletion. Results: Treatment of iron-overloaded rats with curcumin resulted in marked decreases in iron accumulation within liver and spleen. Iron-overloaded rats had significant increases in malonyldialdehyde (MDA), a marker of lipid peroxidation and nitric oxide (NO) in liver and spleen when compared to control group. The effects of iron overload on lipid peroxidation and NO levels were significantly reduced by the intervention treatment with curcumin (P<0.05). Furthermore, the endogenous anti-oxidant activities/levels in liver and spleen were also significantly decreased in chronic iron overload and administration of curcumin restored the decrease in the hepatic and splenic antioxidant activities/levels. Conclusion: Our study suggests that curcumin may represent a new horizon in managing iron overloadinduced toxicity as well as in pathological diseases characterized by hepatic iron accumulation such as thalassemia, sickle cell anemia, and myelodysplastic syndromes possibly via iron chelation, reduced oxidative stress derived lipid peroxidation and improving the body endogenous antioxidant defense mechanism.

Original languageEnglish (US)
Article numbere0134156
JournalPLoS One
Volume10
Issue number7
DOIs
StatePublished - Jul 31 2015

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Curcumin
Oxidative stress
curcumin
Liver
iron overload
Rats
spleen
Oxidative Stress
Iron Overload
oxidative stress
Spleen
Iron
iron
liver
rats
Lipid Peroxidation
lipid peroxidation
antioxidant activity
Oxidants
nitric oxide

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats. / Badria, Farid A.; Ibrahim, Ahmed Salah; Badria, Adel F.; Elmarakby, Ahmed Abdelrazik.

In: PLoS One, Vol. 10, No. 7, e0134156, 31.07.2015.

Research output: Contribution to journalArticle

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