Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration

Justin C. Kennon, Mohamed E. Awad, Norman Chutkan, John Glenden DeVine, Sadanand T Fulzele

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chronic low back pain is a critical health problem and a leading cause of disability in aging populations. A major cause of low back pain is considered to be the degeneration of the intervertebral disc (IVD). Recent advances in therapeutics, particularly cell and tissue engineering, offer potential methods for inhibiting or reversing IVD degeneration, which have previously been impossible. The use of growth factors is under serious consideration as a potential therapy to enhance IVD tissue regeneration. We reviewed the role of chosen prototypical growth factors and growth factor combinations that have the capacity to improve IVD restoration. A number of growth factors have demonstrated potential to modulate the anabolic and anticatabolic effects in both in vitro and animal studies of IVD tissue engineering. Members of the transforming growth factor-β superfamily, IGF-1, GDF-5, BMP-2, BMP-7, and platelet-derived growth factor have all been investigated as possible therapeutic options for IVD regeneration. The role of growth factors in IVD tissue engineering appears promising; however, further extensive research is needed at both basic science and clinical levels before its application is appropriate for clinical use.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalBiomolecular Concepts
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Intervertebral Disc Degeneration
Intervertebral Disc
Intercellular Signaling Peptides and Proteins
Tissue Engineering
Tissue engineering
Low Back Pain
Regeneration
Growth Differentiation Factor 5
Cell engineering
Bone Morphogenetic Protein 7
Cell Engineering
Therapeutics
Anabolic Agents
Tissue regeneration
Platelet-Derived Growth Factor
Bioelectric potentials
Transforming Growth Factors
Medical problems
Insulin-Like Growth Factor I
Restoration

Keywords

  • growth factor
  • intervertebral disc
  • intervertebral disc disease
  • tissue engineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

Cite this

Current insights on use of growth factors as therapy for Intervertebral Disc Degeneration. / Kennon, Justin C.; Awad, Mohamed E.; Chutkan, Norman; DeVine, John Glenden; Fulzele, Sadanand T.

In: Biomolecular Concepts, Vol. 9, No. 1, 01.01.2018, p. 43-52.

Research output: Contribution to journalArticle

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